Detailed information of TA system TA078429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1595941..1596457
• Replicon: chromosome
• Accession: NZ_CP022097
• Organism: Pseudomonas protegens strain FDAARGOS_307

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9XXF1
• Locus tag: CEP86_RS07310
• Protein ID: WP_011058535.1
• Coordinates: 1595941..1596222 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: CEP86_RS07315
• Protein ID: WP_011058534.1
• Coordinates: 1596212..1596457 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP86_RS07290	1592193..1593083	-	891	WP_011058539.1	HlyD family secretion protein	-
CEP86_RS07295	1593080..1593289	-	210	WP_011058538.1	DUF1656 domain-containing protein	-
CEP86_RS07300	1593286..1595373	-	2088	WP_011058537.1	FUSC family protein	-
CEP86_RS07305	1595370..1595798	-	429	WP_011058536.1	winged helix DNA-binding protein	-
CEP86_RS07310	1595941..1596222	-	282	WP_011058535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEP86_RS07315	1596212..1596457	-	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEP86_RS07320	1596522..1596767	-	246	WP_011058533.1	DUF2789 domain-containing protein	-
CEP86_RS07325	1596782..1597243	-	462	WP_011058532.1	YbaK/EbsC family protein	-
CEP86_RS07330	1597353..1598963	-	1611	WP_011058531.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10839.72 Da
• Isoelectric Point: 10.2298

>T78429 WP_011058535.1 NZ_CP022097:c1596222-1595941 [Pseudomonas protegens]
MTYSLEFLPSAHKEWNKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T78429 NZ_CP022097:c1596222-1595941 [Pseudomonas protegens]
ATGACTTATAGCCTTGAGTTCCTGCCTTCGGCACACAAGGAATGGAACAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCTGCTGATGCCCTGCATGGGCTTCCCGATTGCTACAAAATTA
AACTCAAGGCTTCGGGCTACCGATTGGTTTATCAAGTGATCGAAGAGCGCGTCGTGGTTTGCGTGGTTGCGGTCGGCAAG
CGCGAGCGTGGAACCGTTTACGAGCAGGCCAGGAAACGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT78429 WP_011058534.1 NZ_CP022097:c1596457-1596212 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT78429 NZ_CP022097:c1596457-1596212 [Pseudomonas protegens]
ATGCAGAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGTGGTGCCCA
GGGCGGGCCAGTGGCGGTGTTGAATCACAATCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCATCCGCGAGCGCAGCCATGAGACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Structures

Toxin

• AlphaFold DB: F9XXF1

Antitoxin

• AlphaFold DB: Q4KKD3