Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1015530..1016126 Replicon chromosome
Accession NZ_CP022097
Organism Pseudomonas protegens strain FDAARGOS_307

Toxin (Protein)


Gene name relE Uniprot ID Q4KIY8
Locus tag CEP86_RS04745 Protein ID WP_011059021.1
Coordinates 1015530..1015832 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4KIY9
Locus tag CEP86_RS04750 Protein ID WP_011059020.1
Coordinates 1015836..1016126 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP86_RS04725 1010764..1012077 - 1314 WP_041774047.1 precorrin-3B synthase -
CEP86_RS04730 1012216..1013430 + 1215 WP_011059024.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
CEP86_RS04735 1013524..1014621 + 1098 WP_011059023.1 cobalt-precorrin-5B (C(1))-methyltransferase -
CEP86_RS04740 1014618..1015346 + 729 WP_011059022.1 cobalt-precorrin-6A reductase -
CEP86_RS04745 1015530..1015832 + 303 WP_011059021.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEP86_RS04750 1015836..1016126 + 291 WP_011059020.1 putative addiction module antidote protein Antitoxin
CEP86_RS04755 1016227..1016625 + 399 WP_011059019.1 DUF2946 domain-containing protein -
CEP86_RS04760 1016690..1017169 + 480 WP_026020078.1 copper chaperone PCu(A)C -
CEP86_RS04765 1017225..1017635 + 411 WP_011059017.1 DUF2946 domain-containing protein -
CEP86_RS04770 1017724..1019856 + 2133 WP_011059016.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-97)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11499.32 Da        Isoelectric Point: 10.4481

>T78428 WP_011059021.1 NZ_CP022097:1015530-1015832 [Pseudomonas protegens]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEIRIHRGPGYRVYFSRHGKMIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T78428 NZ_CP022097:1015530-1015832 [Pseudomonas protegens]
ATGTTCGTTTTCGAGCAGACTCCTGAGTTCAGCCGCTGGCTGCTGAACCTGAAGGACCCGCAAGGGAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCACAGCTGGGCCGTTTTGGCGACTGCGAACCTGTGGGCGAAGGCGTCCACGAGATACGCATCC
ACCGCGGCCCGGGTTACCGGGTGTACTTCTCGCGCCACGGCAAAATGATCTACCTGCTGTTGATCGGCGGCGACAAGGCC
ACCCAGAAACGCGATATCCAACGGGCCAGGCAACTGGCCTGCGACCTCAAGAGCGAGGGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 5.0939

>AT78428 WP_011059020.1 NZ_CP022097:1015836-1016126 [Pseudomonas protegens]
MRTPVTRFDAAEYLKTPEDMVAYLDACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT78428 NZ_CP022097:1015836-1016126 [Pseudomonas protegens]
ATGCGCACCCCAGTGACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCGTGCTGATCCGCGCCGCACTCAACGACATCGCCCGTGCCCGCGGCATGACCCAGG
TCGCCCGTGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCCCTCGGCAGCCAGGGCAACCCGGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCCCTGGGGTTGAAGATCAACGTCAGCAACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4KIY8

Antitoxin

Source ID Structure
AlphaFold DB Q4KIY9

References