Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 913379..913887 Replicon chromosome
Accession NZ_CP022096
Organism Staphylococcus pettenkoferi strain FDAARGOS_288

Toxin (Protein)


Gene name mazF Uniprot ID A0A2K4FCJ6
Locus tag CEP67_RS04345 Protein ID WP_002471121.1
Coordinates 913379..913717 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K4FCQ5
Locus tag CEP67_RS04350 Protein ID WP_002471108.1
Coordinates 913714..913887 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP67_RS04325 910283..911053 - 771 WP_002471113.1 RNA polymerase sigma factor SigB -
CEP67_RS04330 911028..911507 - 480 WP_002471117.1 anti-sigma B factor RsbW -
CEP67_RS04335 911509..911835 - 327 WP_070504622.1 anti-sigma factor antagonist -
CEP67_RS04340 911914..912915 - 1002 WP_002471118.1 PP2C family protein-serine/threonine phosphatase -
CEP67_RS04345 913379..913717 - 339 WP_002471121.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CEP67_RS04350 913714..913887 - 174 WP_002471108.1 hypothetical protein Antitoxin
CEP67_RS04355 913977..915125 - 1149 WP_088606359.1 alanine racemase -
CEP67_RS04360 915196..915546 - 351 WP_088606360.1 holo-ACP synthase -
CEP67_RS04365 915813..916382 - 570 WP_002471104.1 PH domain-containing protein -
CEP67_RS04370 916369..917871 - 1503 WP_002471115.1 PH domain-containing protein -
CEP67_RS04375 917864..918343 - 480 WP_002471103.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12613.74 Da        Isoelectric Point: 10.3172

>T78423 WP_002471121.1 NZ_CP022096:c913717-913379 [Staphylococcus pettenkoferi]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSDSKMEEVNKAIRISLGLH

Download         Length: 339 bp

>T78423 NZ_CP022096:c913717-913379 [Staphylococcus pettenkoferi]
ATGAGAAGAGGAGATGTTTATTTAGCTGATTTATCACCAGTACAAGGGTCTGAACAAGGGGGAGTAAGACCCGTTGTTAT
CATACAAAACGATACTGGTAATAAATATAGTCCTACCGTAATTGTTGCGGCAATTACGGGTAGGATTAATAAAGCTAAGA
TACCAACCCACGTTGAAATTGAGAAGAAGAAATATAAATTGGACAAAGATTCCGTTATTCTTCTCGAACAAATTCGAACG
TTAGACAAGAAGAGACTTAAGGAAAAGCTTACATATCTATCTGATAGCAAGATGGAAGAAGTCAATAAAGCGATTCGAAT
CAGCTTAGGACTTCATTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6485.05 Da        Isoelectric Point: 4.0121

>AT78423 WP_002471108.1 NZ_CP022096:c913887-913714 [Staphylococcus pettenkoferi]
MSGFNQSRNHSIEQLLKEGYSQMADLNLSLATEAFPFECEACDCNESYISSNFNNER

Download         Length: 174 bp

>AT78423 NZ_CP022096:c913887-913714 [Staphylococcus pettenkoferi]
ATGTCTGGTTTCAATCAAAGTAGGAATCATAGTATCGAACAACTGCTCAAAGAAGGTTACTCCCAAATGGCTGATTTAAA
TCTCTCCCTTGCAACAGAAGCTTTCCCATTTGAATGTGAAGCTTGTGATTGTAACGAATCTTACATCAGTTCCAATTTCA
ATAATGAACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4FCJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4FCQ5

References