Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2385835..2386349 Replicon chromosome
Accession NZ_CP022093
Organism Staphylococcus saprophyticus strain FDAARGOS_355

Toxin (Protein)


Gene name TsdT Uniprot ID Q49Z34
Locus tag CEQ33_RS12100 Protein ID WP_011302693.1
Coordinates 2386143..2386349 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag CEQ33_RS12095 Protein ID WP_002482740.1
Coordinates 2385835..2386128 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ33_RS12070 2380997..2381788 + 792 WP_011302688.1 hydroxyethylthiazole kinase -
CEQ33_RS12075 2381788..2382426 + 639 WP_011302689.1 thiamine phosphate synthase -
CEQ33_RS12080 2382514..2383383 + 870 WP_011302690.1 membrane protein insertase YidC -
CEQ33_RS12085 2383465..2384139 - 675 WP_170178158.1 HD domain-containing protein -
CEQ33_RS12090 2384208..2385692 - 1485 WP_011302692.1 cardiolipin synthase -
CEQ33_RS12095 2385835..2386128 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
CEQ33_RS12100 2386143..2386349 + 207 WP_011302693.1 hypothetical protein Toxin
CEQ33_RS12105 2386562..2386702 + 141 WP_002482742.1 hypothetical protein -
CEQ33_RS12110 2386995..2388200 - 1206 WP_011302694.1 rod shape-determining protein RodA -
CEQ33_RS12115 2388449..2389519 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
CEQ33_RS12120 2389532..2390887 + 1356 WP_011302696.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8040.28 Da        Isoelectric Point: 4.3776

>T78416 WP_011302693.1 NZ_CP022093:2386143-2386349 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSTDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T78416 NZ_CP022093:2386143-2386349 [Staphylococcus saprophyticus]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGACTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTACAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT78416 WP_002482740.1 NZ_CP022093:2385835-2386128 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT78416 NZ_CP022093:2385835-2386128 [Staphylococcus saprophyticus]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q49Z34

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References