Detailed information of TA system TA078405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 1314056..1314621
• Replicon: chromosome
• Accession: NZ_CP022089
• Organism: Shewanella sp. FDAARGOS_354

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8EGZ3
• Locus tag: CEQ32_RS06000
• Protein ID: WP_011071641.1
• Coordinates: 1314328..1314621 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: V1D9S8
• Locus tag: CEQ32_RS05995
• Protein ID: WP_011920070.1
• Coordinates: 1314056..1314340 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ32_RS05955	1309304..1309513	-	210	WP_192959167.1	AlpA family transcriptional regulator	-
CEQ32_RS05960	1309648..1310142	+	495	WP_192959155.1	DNA repair protein RadC	-
CEQ32_RS05965	1310183..1310545	+	363	WP_088585692.1	hypothetical protein	-
CEQ32_RS05970	1310688..1311044	+	357	WP_122040745.1	type IV toxin-antitoxin system YeeU family antitoxin	-
CEQ32_RS05975	1311282..1311695	+	414	WP_088585693.1	DUF2787 domain-containing protein	-
CEQ32_RS05980	1311885..1312292	+	408	WP_088585694.1	DUF2787 domain-containing protein	-
CEQ32_RS05985	1312401..1312967	+	567	WP_037430233.1	site-specific integrase	-
CEQ32_RS05990	1313047..1313769	+	723	WP_069455085.1	lecithin retinol acyltransferase family protein	-
CEQ32_RS05995	1314056..1314340	+	285	WP_011920070.1	CopG family ribbon-helix-helix protein	Antitoxin
CEQ32_RS06000	1314328..1314621	+	294	WP_011071641.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ32_RS06005	1314768..1315445	-	678	WP_069455086.1	inovirus Gp2 family protein	-
CEQ32_RS06010	1315760..1317229	-	1470	WP_069455087.1	DUF3987 domain-containing protein	-
CEQ32_RS06015	1317267..1317479	-	213	WP_080612395.1	AlpA family phage regulatory protein	-
CEQ32_RS06020	1317598..1318689	-	1092	WP_069455088.1	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1303093..1318689	15596

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11125.65 Da
• Isoelectric Point: 5.8404

>T78405 WP_011071641.1 NZ_CP022089:1314328-1314621 [Shewanella sp. FDAARGOS_354]
MPQIVFTATALRDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Nucleotide

• Length: 294 bp

>T78405 NZ_CP022089:1314328-1314621 [Shewanella sp. FDAARGOS_354]
ATGCCACAAATAGTCTTCACTGCCACTGCATTACGTGATTTAGAACGCTTACGTGAGTTTCTTCGCAGTAAAAATCCCCC
TGCCGCACAACGGGCTGCCAGCGCCATAATCAATACCATTAGAAAACTGGAAAGCTATCCAGACATTGGTCGGCCTATCG
ATGACAATGACTTTAGCTTTAGGGAACTGCTCATCGACTTTGGTGATACGGGTTATCTGGCAATGTACCAGTATGATGGC
GGCGAACGATTGACCGTATTGTGTATCCGTCACCAAAAAGAAGCCGGATATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10955.29 Da
• Isoelectric Point: 6.3342

>AT78405 WP_011920070.1 NZ_CP022089:1314056-1314340 [Shewanella sp. FDAARGOS_354]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEKAAPTCHK

Nucleotide

• Length: 285 bp

>AT78405 NZ_CP022089:1314056-1314340 [Shewanella sp. FDAARGOS_354]
ATGAGCACAATCAAACCCGTGTCGGTTAAATTAGATGCCGATATTAAAGCCAGAGTCGAGCATTTAGCCGAAACCCGTAA
ACGTTCATCACACTGGATGATGCGTGAAGCGATCCGTGAATACGTTGAGAGAGAAGAGAAACGCGAAGCTTTGCAGCAAG
AAGCGTTACGCGCATGGGAAGAACACCAGACATCAGGCTTGCATGTCACCGGTGACGAAGTGGTAAGTTGGCTGGAGTCC
TGGGGGAGTGAAAATGAAAAGGCAGCCCCTACATGCCACAAATAG

Structures

Toxin

• PDB: 7ETR

Antitoxin

• AlphaFold DB: V1D9S8