Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 173563..174379 Replicon chromosome
Accession NZ_CP022089
Organism Shewanella sp. FDAARGOS_354

Toxin (Protein)


Gene name hepT Uniprot ID A0A252EQR5
Locus tag CEQ32_RS00885 Protein ID WP_069455295.1
Coordinates 173563..173964 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A501X4H4
Locus tag CEQ32_RS00890 Protein ID WP_069455294.1
Coordinates 173957..174379 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ32_RS00865 168632..168922 + 291 WP_052184036.1 transposase -
CEQ32_RS00870 168943..170352 - 1410 WP_088585341.1 ammonia-forming cytochrome c nitrite reductase subunit c552 -
CEQ32_RS00875 170336..171547 - 1212 WP_088585342.1 NnrS family protein -
CEQ32_RS00880 172338..173369 + 1032 WP_088585343.1 dTDP-glucose 4,6-dehydratase -
CEQ32_RS00885 173563..173964 - 402 WP_069455295.1 type II toxin-antitoxin system toxin Toxin
CEQ32_RS00890 173957..174379 - 423 WP_069455294.1 type II toxin-antitoxin system antitoxin Antitoxin
CEQ32_RS00895 174486..175253 - 768 WP_086904479.1 HutD family protein -
CEQ32_RS00900 175529..175975 - 447 WP_192959140.1 copper resistance protein NlpE -
CEQ32_RS00905 176149..177357 + 1209 WP_001206290.1 IS4-like element IS10A family transposase -
CEQ32_RS00910 177703..179064 + 1362 WP_088585345.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 176149..177357 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15296.57 Da        Isoelectric Point: 6.3185

>T78403 WP_069455295.1 NZ_CP022089:c173964-173563 [Shewanella sp. FDAARGOS_354]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

>T78403 NZ_CP022089:c173964-173563 [Shewanella sp. FDAARGOS_354]
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGAAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCGCAGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGCAGTACATGACTACCAAGAACT
CAACCTTGATATCGTTGTCCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15795.88 Da        Isoelectric Point: 5.1520

>AT78403 WP_069455294.1 NZ_CP022089:c174379-173957 [Shewanella sp. FDAARGOS_354]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Download         Length: 423 bp

>AT78403 NZ_CP022089:c174379-173957 [Shewanella sp. FDAARGOS_354]
ATGCAACAACTAAATGAAAAGAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACA
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGATC
ATAGGGGGAGTCACTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252EQR5

Antitoxin

Source ID Structure
AlphaFold DB A0A501X4H4

References