Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 7110809..7111335 Replicon chromosome
Accession NZ_CP022088
Organism Nocardia brasiliensis strain FDAARGOS_352

Toxin (Protein)


Gene name relE Uniprot ID A0A0C1B8J3
Locus tag CEQ30_RS31945 Protein ID WP_042260220.1
Coordinates 7110809..7111066 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A379A4Z5
Locus tag CEQ30_RS31950 Protein ID WP_042260254.1
Coordinates 7111063..7111335 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ30_RS31920 7106433..7106777 + 345 WP_014988735.1 DUF3263 domain-containing protein -
CEQ30_RS31925 7106797..7107384 + 588 WP_081869109.1 LytR C-terminal domain-containing protein -
CEQ30_RS31930 7107515..7108201 + 687 WP_029893174.1 superoxide dismutase family protein -
CEQ30_RS31935 7108215..7109360 + 1146 WP_042260217.1 glutamate--cysteine ligase -
CEQ30_RS31940 7109491..7110789 + 1299 WP_042260219.1 phosphatase PAP2 family protein -
CEQ30_RS31945 7110809..7111066 - 258 WP_042260220.1 Txe/YoeB family addiction module toxin Toxin
CEQ30_RS31950 7111063..7111335 - 273 WP_042260254.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CEQ30_RS31955 7111394..7111729 - 336 WP_042260222.1 monovalent cation/H(+) antiporter subunit G -
CEQ30_RS31960 7111761..7112021 - 261 WP_042260255.1 monovalent cation/H+ antiporter subunit F -
CEQ30_RS31965 7112018..7112587 - 570 WP_014988727.1 Na+/H+ antiporter subunit E -
CEQ30_RS31970 7112584..7114200 - 1617 WP_042260225.1 Na+/H+ antiporter subunit D -
CEQ30_RS31975 7114197..7114580 - 384 WP_014988725.1 Na(+)/H(+) antiporter subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10052.42 Da        Isoelectric Point: 8.0704

>T78400 WP_042260220.1 NZ_CP022088:c7111066-7110809 [Nocardia brasiliensis]
VKILFTPDAWADYLWWQAHDRATLKRVNKLIDDITRNGYEGIGKPEALRQNLAGFWSRRITSEHRIVYVIEDDTAKIVAC
RHHYE

Download         Length: 258 bp

>T78400 NZ_CP022088:c7111066-7110809 [Nocardia brasiliensis]
GTGAAGATTCTCTTCACGCCCGACGCGTGGGCCGACTATCTGTGGTGGCAGGCCCACGACCGCGCGACCCTCAAACGCGT
CAACAAACTGATCGACGACATCACACGCAACGGCTACGAAGGAATCGGTAAGCCAGAAGCATTGCGCCAGAACCTCGCCG
GATTCTGGTCTCGACGCATCACCAGCGAACATCGCATCGTGTACGTCATCGAGGACGACACGGCGAAGATCGTCGCCTGC
CGTCACCACTACGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9776.87 Da        Isoelectric Point: 4.2492

>AT78400 WP_042260254.1 NZ_CP022088:c7111335-7111063 [Nocardia brasiliensis]
MRPISITEARANLAAVLDSATEDLEEVVITRAGHEPAVVISLREYESLKETAYLLGNPANARHLERSIAQLRAGEAAPHD
LIEVDDEDSA

Download         Length: 273 bp

>AT78400 NZ_CP022088:c7111335-7111063 [Nocardia brasiliensis]
ATGCGTCCGATATCCATCACCGAAGCACGCGCCAACCTAGCGGCAGTCCTGGATTCCGCCACTGAGGATCTAGAGGAAGT
CGTCATCACCCGGGCTGGGCACGAGCCCGCGGTCGTTATTTCGCTTCGCGAGTACGAGTCGTTGAAGGAGACCGCCTATC
TCTTGGGCAACCCGGCGAACGCTCGCCACCTGGAGAGGTCGATCGCTCAACTCCGAGCTGGAGAGGCAGCGCCGCACGAT
CTCATCGAGGTCGACGATGAGGACAGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1B8J3

Antitoxin

Source ID Structure
AlphaFold DB A0A379A4Z5

References