Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 64774..65333 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP022087 | ||
| Organism | Escherichia coli O104:H4 strain FDAARGOS_348 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G4VUF8 |
| Locus tag | CEQ26_RS28815 | Protein ID | WP_000421273.1 |
| Coordinates | 64774..65049 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0SRR3 |
| Locus tag | CEQ26_RS28820 | Protein ID | WP_001387467.1 |
| Coordinates | 65049..65333 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEQ26_RS28770 | 59816..60046 | + | 231 | WP_001261288.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| CEQ26_RS28775 | 60070..60471 | + | 402 | WP_001392130.1 | type II toxin-antitoxin system VapC family toxin | - |
| CEQ26_RS28780 | 60554..60703 | - | 150 | Protein_70 | transposase domain-containing protein | - |
| CEQ26_RS28790 | 61795..62772 | + | 978 | WP_001387465.1 | RepB family plasmid replication initiator protein | - |
| CEQ26_RS28795 | 63051..63791 | - | 741 | WP_001066951.1 | tyrosine-type recombinase/integrase | - |
| CEQ26_RS28800 | 63912..64037 | - | 126 | WP_032159539.1 | hypothetical protein | - |
| CEQ26_RS28805 | 64160..64321 | - | 162 | WP_001440647.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CEQ26_RS28810 | 64437..64768 | - | 332 | Protein_75 | type II toxin-antitoxin system ParD family antitoxin | - |
| CEQ26_RS28815 | 64774..65049 | - | 276 | WP_000421273.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CEQ26_RS28820 | 65049..65333 | - | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| CEQ26_RS28835 | 66241..67069 | - | 829 | Protein_78 | incFII family plasmid replication initiator RepA | - |
| CEQ26_RS28840 | 67062..67136 | - | 75 | WP_014966221.1 | RepA leader peptide Tap | - |
| CEQ26_RS29750 | 67133..67267 | - | 135 | Protein_80 | protein CopA/IncA | - |
| CEQ26_RS28850 | 67374..67628 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| CEQ26_RS28855 | 67909..68889 | + | 981 | WP_000019427.1 | IS5-like element ISKpn26 family transposase | - |
| CEQ26_RS28870 | 69340..69552 | - | 213 | Protein_83 | ANR family transcriptional regulator | - |
| CEQ26_RS28875 | 69617..70294 | + | 678 | WP_001339397.1 | IS66 family insertion sequence hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | aap/aspU / aggA / aggB / aggC / aggD | 1..75559 | 75559 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10765.45 Da Isoelectric Point: 9.9324
>T78397 WP_000421273.1 NZ_CP022087:c65049-64774 [Escherichia coli O104:H4]
MELKWTSKALSDLSRLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T78397 NZ_CP022087:c65049-64774 [Escherichia coli O104:H4]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT78397 WP_001387467.1 NZ_CP022087:c65333-65049 [Escherichia coli O104:H4]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT78397 NZ_CP022087:c65333-65049 [Escherichia coli O104:H4]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y6H1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y880 |