Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3913703..3914504 Replicon chromosome
Accession NZ_CP022086
Organism Escherichia coli O104:H4 strain FDAARGOS_348

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag CEQ26_RS21515 Protein ID WP_001094437.1
Coordinates 3914127..3914504 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag CEQ26_RS21510 Protein ID WP_001390338.1
Coordinates 3913703..3914080 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ26_RS21475 3910821..3910979 + 159 WP_001323397.1 DUF905 family protein -
CEQ26_RS21485 3911134..3911952 + 819 WP_001234716.1 DUF945 domain-containing protein -
CEQ26_RS29520 3911952..3912125 + 174 WP_001183321.1 hypothetical protein -
CEQ26_RS21495 3912291..3912764 + 474 WP_001387789.1 antirestriction protein -
CEQ26_RS21500 3912780..3913256 + 477 WP_001186773.1 RadC family protein -
CEQ26_RS21505 3913319..3913540 + 222 WP_000692300.1 DUF987 domain-containing protein -
CEQ26_RS21510 3913703..3914080 + 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEQ26_RS21515 3914127..3914504 + 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
CEQ26_RS21520 3914501..3914989 + 489 WP_000761716.1 hypothetical protein -
CEQ26_RS21525 3915009..3915206 + 198 WP_000772032.1 DUF957 domain-containing protein -
CEQ26_RS21530 3915291..3916136 + 846 WP_001274561.1 DUF4942 domain-containing protein -
CEQ26_RS21545 3916929..3918113 + 1185 WP_001172875.1 sugar efflux transporter -
CEQ26_RS21550 3918224..3919147 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / qacE / dfrA7 / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) - 3870285..3914504 44219


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T78389 WP_001094437.1 NZ_CP022086:3914127-3914504 [Escherichia coli O104:H4]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T78389 NZ_CP022086:3914127-3914504 [Escherichia coli O104:H4]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT78389 WP_001390338.1 NZ_CP022086:3913703-3914080 [Escherichia coli O104:H4]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT78389 NZ_CP022086:3913703-3914080 [Escherichia coli O104:H4]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References