Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3100445..3101246 | Replicon | chromosome |
| Accession | NZ_CP022086 | ||
| Organism | Escherichia coli O104:H4 strain FDAARGOS_348 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D3GU15 |
| Locus tag | CEQ26_RS17180 | Protein ID | WP_001094429.1 |
| Coordinates | 3100869..3101246 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0XUQ1 |
| Locus tag | CEQ26_RS17175 | Protein ID | WP_001285616.1 |
| Coordinates | 3100445..3100822 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEQ26_RS17135 | 3097106..3097561 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| CEQ26_RS17140 | 3097640..3097873 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| CEQ26_RS17150 | 3097973..3098791 | + | 819 | WP_001234603.1 | DUF945 domain-containing protein | - |
| CEQ26_RS17160 | 3099093..3099566 | + | 474 | WP_000855081.1 | antirestriction protein | - |
| CEQ26_RS17165 | 3099582..3100057 | + | 476 | Protein_3002 | RadC family protein | - |
| CEQ26_RS17170 | 3100144..3100365 | + | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| CEQ26_RS17175 | 3100445..3100822 | + | 378 | WP_001285616.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CEQ26_RS17180 | 3100869..3101246 | + | 378 | WP_001094429.1 | TA system toxin CbtA family protein | Toxin |
| CEQ26_RS17185 | 3101243..3101440 | + | 198 | Protein_3006 | hypothetical protein | - |
| CEQ26_RS17190 | 3101468..3101665 | + | 198 | WP_085949090.1 | DUF957 domain-containing protein | - |
| CEQ26_RS17195 | 3101750..3102592 | + | 843 | WP_001280493.1 | DUF4942 domain-containing protein | - |
| CEQ26_RS17200 | 3102873..3103409 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| CEQ26_RS17205 | 3103411..3104589 | - | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| CEQ26_RS17210 | 3104586..3105563 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| CEQ26_RS17215 | 3105566..3106165 | - | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | pic / pic / pic / pic / clbK / vipB/tssC / vipA/tssB / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3027061..3166066 | 139005 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13856.73 Da Isoelectric Point: 6.8601
>T78387 WP_001094429.1 NZ_CP022086:3100869-3101246 [Escherichia coli O104:H4]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T78387 NZ_CP022086:3100869-3101246 [Escherichia coli O104:H4]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13747.65 Da Isoelectric Point: 6.6240
>AT78387 WP_001285616.1 NZ_CP022086:3100445-3100822 [Escherichia coli O104:H4]
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTMTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTMTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT78387 NZ_CP022086:3100445-3100822 [Escherichia coli O104:H4]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCATGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCATGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVU5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XUQ1 |