Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2007353..2008574 | Replicon | chromosome |
| Accession | NZ_CP022084 | ||
| Organism | Burkholderia cepacia strain FDAARGOS_345 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A806V019 |
| Locus tag | CEQ23_RS33950 | Protein ID | WP_027789605.1 |
| Coordinates | 2007993..2008574 (+) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A806V242 |
| Locus tag | CEQ23_RS33945 | Protein ID | WP_027789604.1 |
| Coordinates | 2007353..2007910 (+) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEQ23_RS33920 | 2002749..2003480 | - | 732 | WP_027789599.1 | ribonuclease T2 | - |
| CEQ23_RS33925 | 2003711..2004100 | + | 390 | WP_027789600.1 | OsmC family protein | - |
| CEQ23_RS33930 | 2004182..2004760 | - | 579 | WP_027789601.1 | hypothetical protein | - |
| CEQ23_RS33935 | 2004857..2006260 | - | 1404 | WP_027789602.1 | membrane protein | - |
| CEQ23_RS33940 | 2006621..2007298 | + | 678 | WP_027789603.1 | hypothetical protein | - |
| CEQ23_RS33945 | 2007353..2007910 | + | 558 | WP_027789604.1 | helix-turn-helix domain-containing protein | Antitoxin |
| CEQ23_RS33950 | 2007993..2008574 | + | 582 | WP_027789605.1 | HD domain-containing protein | Toxin |
| CEQ23_RS33955 | 2008630..2009358 | + | 729 | WP_027789606.1 | class I SAM-dependent methyltransferase | - |
| CEQ23_RS33960 | 2009643..2010836 | + | 1194 | WP_027789607.1 | macrolide transporter subunit MacA | - |
| CEQ23_RS33965 | 2010839..2012899 | + | 2061 | WP_027789608.1 | MacB family efflux pump subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21301.86 Da Isoelectric Point: 4.9552
>T78368 WP_027789605.1 NZ_CP022084:2007993-2008574 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPARRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHE
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPARRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHE
Download Length: 582 bp
>T78368 NZ_CP022084:2007993-2008574 [Burkholderia cepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGTGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCACGGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAACCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGGGTGGGCAGCACGAGTAA
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGTGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCACGGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAACCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGGGTGGGCAGCACGAGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 19990.98 Da Isoelectric Point: 10.2051
>AT78368 WP_027789604.1 NZ_CP022084:2007353-2007910 [Burkholderia cepacia]
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERAAAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGAAARLVETL
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERAAAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGAAARLVETL
Download Length: 558 bp
>AT78368 NZ_CP022084:2007353-2007910 [Burkholderia cepacia]
ATGTCTGCCTCACCGCTACACGCACCACCACTCGGCCCGCAACTCAAGCGCTGGCGAGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGGCGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTACTTGCCTGTTCGCCCGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGGCGGCCGCGCGGCTCGTGGAAACGCTGTAA
ATGTCTGCCTCACCGCTACACGCACCACCACTCGGCCCGCAACTCAAGCGCTGGCGAGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGGCGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTACTTGCCTGTTCGCCCGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGGCGGCCGCGCGGCTCGTGGAAACGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806V019 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806V242 |