Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1723320..1725070 Replicon chromosome
Accession NZ_CP022084
Organism Burkholderia cepacia strain FDAARGOS_345

Toxin (Protein)


Gene name doc Uniprot ID A0A806V0L2
Locus tag CEQ23_RS32590 Protein ID WP_027789380.1
Coordinates 1724174..1725070 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4S5DGT0
Locus tag CEQ23_RS32585 Protein ID WP_027789379.1
Coordinates 1723320..1724177 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ23_RS32565 1718483..1719973 - 1491 WP_027789375.1 aldehyde dehydrogenase -
CEQ23_RS32570 1720046..1720873 - 828 WP_027789376.1 aspartate dehydrogenase -
CEQ23_RS32575 1720866..1722533 - 1668 WP_027789377.1 thiamine pyrophosphate-binding protein -
CEQ23_RS32580 1722526..1723323 - 798 WP_027789378.1 SDR family oxidoreductase -
CEQ23_RS32585 1723320..1724177 - 858 WP_027789379.1 IclR family transcriptional regulator Antitoxin
CEQ23_RS32590 1724174..1725070 - 897 WP_027789380.1 alpha/beta fold hydrolase Toxin
CEQ23_RS32595 1725089..1725616 - 528 WP_021161513.1 cupin domain-containing protein -
CEQ23_RS32600 1725650..1726420 - 771 WP_027789381.1 SDR family oxidoreductase -
CEQ23_RS32605 1726413..1727483 - 1071 WP_027789382.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CEQ23_RS32610 1727538..1727849 - 312 WP_027789383.1 hypothetical protein -
CEQ23_RS32615 1727853..1728170 - 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
CEQ23_RS32620 1728616..1729695 + 1080 WP_027789386.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30635.82 Da        Isoelectric Point: 7.7327

>T78366 WP_027789380.1 NZ_CP022084:c1725070-1724174 [Burkholderia cepacia]
MSVIDKRERDRTATFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA

Download         Length: 897 bp

>T78366 NZ_CP022084:c1725070-1724174 [Burkholderia cepacia]
ATGAGTGTCATCGACAAACGTGAGCGCGACCGCACCGCGACGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCCTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GAATCGCGCCGCGACGCACGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGGCATGCCGGTTATGTCGAGGCTCCGGCCGTCTATTCCGCACTGATCGACTCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31511.04 Da        Isoelectric Point: 6.5068

>AT78366 WP_027789379.1 NZ_CP022084:c1724177-1723320 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT78366 NZ_CP022084:c1724177-1723320 [Burkholderia cepacia]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAGTCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTTGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTCTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCACTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGCGGCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V0L2

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5DGT0

References