Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3162430..3163103 Replicon chromosome
Accession NZ_CP022083
Organism Burkholderia cepacia strain FDAARGOS_345

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5X1U9
Locus tag CEQ23_RS21615 Protein ID WP_027787436.1
Coordinates 3162430..3162846 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A4S5D574
Locus tag CEQ23_RS21620 Protein ID WP_049096496.1
Coordinates 3162843..3163103 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ23_RS21595 3158230..3158769 - 540 WP_027787432.1 outer membrane protein assembly factor BamE -
CEQ23_RS21600 3158923..3160086 - 1164 WP_027787433.1 amidohydrolase -
CEQ23_RS21605 3160428..3161501 + 1074 WP_027787434.1 hypothetical protein -
CEQ23_RS21610 3161470..3162375 + 906 WP_027787435.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CEQ23_RS21615 3162430..3162846 - 417 WP_027787436.1 PIN domain-containing protein Toxin
CEQ23_RS21620 3162843..3163103 - 261 WP_049096496.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CEQ23_RS21625 3163354..3164370 - 1017 WP_027787437.1 acetyltransferase -
CEQ23_RS21630 3164370..3165209 - 840 WP_027787438.1 N(5)-hydroxyornithine transformylase PvdF -
CEQ23_RS21635 3165296..3167548 - 2253 WP_027787439.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14536.66 Da        Isoelectric Point: 7.8895

>T78361 WP_027787436.1 NZ_CP022083:c3162846-3162430 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T78361 NZ_CP022083:c3162846-3162430 [Burkholderia cepacia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCGACGGCCGCGATTCGTGCCGATCTCGCCGCGCGCGGCACGCCGATCGGTGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCCGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAATTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9564.84 Da        Isoelectric Point: 4.6151

>AT78361 WP_049096496.1 NZ_CP022083:c3163103-3162843 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLMLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT78361 NZ_CP022083:c3163103-3162843 [Burkholderia cepacia]
ATGCGTACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACACTGATGCTGCGGCCGGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5X1U9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5D574

References