Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE-vagC/RelE-VagC
Location 1130048..1130705 Replicon chromosome
Accession NZ_CP022083
Organism Burkholderia cepacia strain FDAARGOS_345

Toxin (Protein)


Gene name parE Uniprot ID A0A1Z3YPK5
Locus tag CEQ23_RS11785 Protein ID WP_027788679.1
Coordinates 1130421..1130705 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag CEQ23_RS11780 Protein ID WP_027788678.1
Coordinates 1130048..1130284 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ23_RS11765 1127025..1128161 + 1137 WP_027788675.1 alginate lyase family protein -
CEQ23_RS11770 1128192..1129580 + 1389 WP_027788676.1 L-serine ammonia-lyase -
CEQ23_RS11775 1129647..1130048 - 402 WP_027788677.1 type II toxin-antitoxin system VapC family toxin -
CEQ23_RS11780 1130048..1130284 - 237 WP_027788678.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CEQ23_RS11785 1130421..1130705 - 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CEQ23_RS11790 1130702..1131163 - 462 WP_027788680.1 hypothetical protein -
CEQ23_RS11795 1131464..1133167 + 1704 WP_027788681.1 thiamine pyrophosphate-binding protein -
CEQ23_RS11800 1133164..1134306 + 1143 WP_049097352.1 ADP-heptose--LPS heptosyltransferase -
CEQ23_RS11810 1134505..1135536 - 1032 WP_027788682.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10794.40 Da        Isoelectric Point: 5.7133

>T78360 WP_027788679.1 NZ_CP022083:c1130705-1130421 [Burkholderia cepacia]
MTLALHWNPKAYEDRAAIMDYIGEDDPQAAIELDELLEQRAATLPARAELYRQGRVAGTRELVVAPNYVLVYRIRPAEGI
VEILRVLHARRQWP

Download         Length: 285 bp

>T78360 NZ_CP022083:c1130705-1130421 [Burkholderia cepacia]
TTGACCCTCGCGCTGCACTGGAATCCGAAGGCGTACGAGGATCGCGCCGCGATCATGGACTACATCGGCGAGGACGACCC
GCAGGCCGCAATCGAACTCGACGAACTGCTGGAACAAAGGGCCGCCACGTTGCCGGCCCGTGCAGAGCTGTATCGGCAAG
GGCGAGTGGCCGGCACGCGCGAACTGGTGGTCGCGCCGAACTACGTGCTCGTGTATCGCATCAGACCGGCTGAGGGGATC
GTCGAGATCCTCCGCGTGCTGCATGCGCGACGGCAGTGGCCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT78360 WP_027788678.1 NZ_CP022083:c1130284-1130048 [Burkholderia cepacia]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT78360 NZ_CP022083:c1130284-1130048 [Burkholderia cepacia]
ATGCACACGACGAAGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTCGCCTATGAGCGTAACGA
TATCGAACTGGAAATCGAGCGTATCGGTGACGAAATCCGTATTCGACCGATGCGGCGGCCGTTGACCCGCGTACTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGCGGCGACCAGGAGCAGGCCGATCGCGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3YPK5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References