Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4131076..4131715 Replicon chromosome
Accession NZ_CP022073
Organism Citrobacter koseri strain FDAARGOS_287

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CEP66_RS20250 Protein ID WP_072271874.1
Coordinates 4131076..4131252 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CEP66_RS20255 Protein ID WP_125337124.1
Coordinates 4131299..4131715 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP66_RS20230 4126169..4127044 + 876 WP_012132344.1 AraC family transcriptional regulator -
CEP66_RS20235 4127021..4128187 - 1167 WP_058669187.1 benzoate/H(+) symporter BenE family transporter -
CEP66_RS20240 4128280..4128816 + 537 WP_058669186.1 XRE family transcriptional regulator -
CEP66_RS20245 4128895..4130856 + 1962 WP_058669433.1 U32 family peptidase -
CEP66_RS20250 4131076..4131252 + 177 WP_072271874.1 type II toxin-antitoxin system HicA family toxin Toxin
CEP66_RS20255 4131299..4131715 + 417 WP_125337124.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CEP66_RS20260 4131766..4133175 + 1410 WP_058669185.1 PLP-dependent aminotransferase family protein -
CEP66_RS20265 4133495..4134919 + 1425 WP_060816081.1 aminobutyraldehyde dehydrogenase -
CEP66_RS20270 4135018..4135113 - 96 WP_071818853.1 stress response membrane protein YncL -
CEP66_RS20275 4135305..4135478 + 174 WP_049008504.1 GhoT/OrtT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6794.76 Da        Isoelectric Point: 10.8122

>T78356 WP_072271874.1 NZ_CP022073:4131076-4131252 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQPGLN

Download         Length: 177 bp

>T78356 NZ_CP022073:4131076-4131252 [Citrobacter koseri]
GTGAAGCAAAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAGCGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCCTGGTTTGAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15370.62 Da        Isoelectric Point: 4.4377

>AT78356 WP_125337124.1 NZ_CP022073:4131299-4131715 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp

>AT78356 NZ_CP022073:4131299-4131715 [Citrobacter koseri]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAATCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGAAGCTGATGATTATGTGGAGATTCCTCTTAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTGAAACACGCAACGAAAATCGATGCTGTACAGATTGCGGCCAGAGCATTGGGTAAAGAGTTAT
CGCTGACTATGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References