Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 508440..509143 Replicon chromosome
Accession NZ_CP022073
Organism Citrobacter koseri strain FDAARGOS_287

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag CEP66_RS02445 Protein ID WP_058668643.1
Coordinates 508440..508805 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CEP66_RS02450 Protein ID WP_058668642.1
Coordinates 508826..509143 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP66_RS02425 504166..504648 + 483 WP_012133757.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
CEP66_RS02430 504645..505868 + 1224 WP_058668646.1 Zn-dependent hydrolase -
CEP66_RS02435 506138..507121 + 984 WP_058668645.1 DUF1852 domain-containing protein -
CEP66_RS02440 507149..508180 + 1032 WP_058668644.1 methionine synthase -
CEP66_RS02445 508440..508805 - 366 WP_058668643.1 TA system toxin CbtA family protein Toxin
CEP66_RS02450 508826..509143 - 318 WP_058668642.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEP66_RS02455 509161..509382 - 222 WP_058668641.1 DUF987 domain-containing protein -
CEP66_RS02460 509391..509873 - 483 WP_058668640.1 DNA repair protein RadC -
CEP66_RS02465 509882..510340 - 459 WP_058668639.1 antirestriction protein -
CEP66_RS02470 510443..510714 - 272 Protein_469 DUF905 family protein -
CEP66_RS02475 510981..511778 + 798 WP_125337065.1 hypothetical protein -
CEP66_RS02480 512357..512821 - 465 WP_058668636.1 hypothetical protein -
CEP66_RS02485 512845..513285 - 441 WP_058668635.1 hypothetical protein -
CEP66_RS02490 513285..513521 - 237 WP_001144029.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13610.76 Da        Isoelectric Point: 8.2762

>T78344 WP_058668643.1 NZ_CP022073:c508805-508440 [Citrobacter koseri]
MKTLPATISRAAKPCLSPVAVWQMLLARLLEKHYGLTLNDTPFFDESVIQEHIDAGITLANAVNFLVEKYELVRINRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSR

Download         Length: 366 bp

>T78344 NZ_CP022073:c508805-508440 [Citrobacter koseri]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCTCCAGTGGCTGTCTGGCAAATGTTACTGGC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTTTGATGAATCCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAAAAGTATGAGTTAGTACGTATCAATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGTGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11949.62 Da        Isoelectric Point: 7.3230

>AT78344 WP_058668642.1 NZ_CP022073:c509143-508826 [Citrobacter koseri]
MKNTTWGLQRDITPRLGARLMQEGNRLHYLADRASITGKFSDTECLKLDFAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT78344 NZ_CP022073:c509143-508826 [Citrobacter koseri]
ATGAAAAACACCACATGGGGCCTACAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGATGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATACCGAATGCCTGAAGTTGGATTTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATATATCGCTGTTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References