Detailed information of TA system TA078342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 19585..20107
• Replicon: plasmid unnamed2
• Accession: NZ_CP022072
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain FDAARGOS_321

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: CEP99_RS25895
• Protein ID: WP_000220560.1
• Coordinates: 19826..20107 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: CEP99_RS25890
• Protein ID: WP_000121743.1
• Coordinates: 19585..19836 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP99_RS25855	15172..15456	+	285	WP_001185480.1	hypothetical protein	-
CEP99_RS26340	15891..16076	+	186	Protein_17	YcxB family protein	-
CEP99_RS26345	16254..16487	+	234	WP_024252801.1	YcxB family protein	-
CEP99_RS25870	16539..16964	-	426	WP_000202953.1	hypothetical protein	-
CEP99_RS25875	17032..17478	-	447	WP_001074386.1	hypothetical protein	-
CEP99_RS25880	17518..18354	-	837	WP_001050931.1	replication initiation protein	-
CEP99_RS25890	19585..19836	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
CEP99_RS25895	19826..20107	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEP99_RS25900	20253..20576	+	324	WP_001181903.1	hypothetical protein	-
CEP99_RS25905	20621..20866	+	246	WP_000356546.1	hypothetical protein	-
CEP99_RS25910	20856..21071	+	216	WP_001180116.1	hypothetical protein	-
CEP99_RS25915	21164..21493	+	330	WP_001556724.1	hypothetical protein	-
CEP99_RS25920	21536..21715	+	180	WP_000439078.1	hypothetical protein	-
CEP99_RS26350	21785..21934	+	150	WP_000003880.1	hypothetical protein	-
CEP99_RS25930	21947..22219	+	273	WP_000160399.1	hypothetical protein	-
CEP99_RS26355	22476..22550	+	75	Protein_31	DNA distortion polypeptide 3	-
CEP99_RS25940	22545..23090	+	546	WP_001556723.1	hypothetical protein	-
CEP99_RS25945	23093..24259	+	1167	WP_000539530.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..42327	42327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T78342 WP_000220560.1 NZ_CP022072:19826-20107 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T78342 NZ_CP022072:19826-20107 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT78342 WP_000121743.1 NZ_CP022072:19585-19836 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT78342 NZ_CP022072:19585-19836 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301