Detailed information of TA system TA078340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 55054..55579
• Replicon: plasmid unnamed1
• Accession: NZ_CP022071
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain FDAARGOS_321

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: CEP99_RS25530
• Protein ID: WP_001159863.1
• Coordinates: 55054..55359 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: CEP99_RS25535
• Protein ID: WP_000813641.1
• Coordinates: 55361..55579 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP99_RS25490	50433..50993	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
CEP99_RS26325	51149..51436	+	288	WP_071530243.1	hypothetical protein	-
CEP99_RS25495	51713..52198	-	486	WP_000905606.1	membrane protein	-
CEP99_RS25500	52192..52701	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
CEP99_RS25510	52705..53418	-	714	Protein_68	EAL domain-containing protein	-
CEP99_RS25515	53427..54209	-	783	WP_000082169.1	site-specific integrase	-
CEP99_RS25520	54244..54765	-	522	WP_000198608.1	hypothetical protein	-
CEP99_RS25525	54762..55052	-	291	WP_001266176.1	hypothetical protein	-
CEP99_RS25530	55054..55359	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
CEP99_RS25535	55361..55579	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CEP99_RS25540	56255..56776	+	522	WP_010999942.1	hypothetical protein	-
CEP99_RS25550	57260..57556	+	297	WP_001687482.1	hypothetical protein	-
CEP99_RS25555	58050..59039	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
CEP99_RS25560	59298..59742	-	445	Protein_77	site-specific integrase	-
CEP99_RS25565	59911..60292	-	382	Protein_78	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93862	93862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T78340 WP_001159863.1 NZ_CP022071:c55359-55054 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T78340 NZ_CP022071:c55359-55054 [Salmonella enterica subsp. enterica serovar Typhimurium]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT78340 WP_000813641.1 NZ_CP022071:c55579-55361 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT78340 NZ_CP022071:c55579-55361 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6