Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 35881..36406 Replicon plasmid unnamed4
Accession NZ_CP022064
Organism Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain FDAARGOS_312

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag CEP90_RS26630 Protein ID WP_001159871.1
Coordinates 36101..36406 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag CEP90_RS26625 Protein ID WP_000813630.1
Coordinates 35881..36099 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP90_RS26590 30882..31472 - 591 WP_000194550.1 hypothetical protein -
CEP90_RS26595 31472..31726 - 255 WP_000343103.1 hypothetical protein -
CEP90_RS26600 32078..33079 + 1002 WP_000774875.1 DUF4238 domain-containing protein -
CEP90_RS26605 33255..33599 - 345 WP_000793307.1 hypothetical protein -
CEP90_RS26610 34098..34352 - 255 WP_000678527.1 hypothetical protein -
CEP90_RS26615 34397..35323 - 927 WP_001290416.1 hypothetical protein -
CEP90_RS26625 35881..36099 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CEP90_RS26630 36101..36406 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
CEP90_RS26635 36407..37213 + 807 WP_000016969.1 site-specific integrase -
CEP90_RS26640 37393..38037 + 645 WP_001144036.1 ParA family protein -
CEP90_RS26645 38124..38432 + 309 WP_000030199.1 hypothetical protein -
CEP90_RS26650 38846..39826 + 981 WP_000688514.1 plasmid segregation protein ParM -
CEP90_RS26655 39819..40235 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..109170 109170


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T78339 WP_001159871.1 NZ_CP022064:36101-36406 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T78339 NZ_CP022064:36101-36406 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT78339 WP_000813630.1 NZ_CP022064:35881-36099 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT78339 NZ_CP022064:35881-36099 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References