Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2650..3172 Replicon plasmid unnamed2
Accession NZ_CP022061
Organism Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain FDAARGOS_312

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag CEP90_RS00105 Protein ID WP_000220560.1
Coordinates 2891..3172 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag CEP90_RS00100 Protein ID WP_000121743.1
Coordinates 2650..2901 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP90_RS00085 576..1415 - 840 WP_001682416.1 replication initiation protein -
CEP90_RS00100 2650..2901 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
CEP90_RS00105 2891..3172 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEP90_RS00110 3318..3641 + 324 WP_001181903.1 hypothetical protein -
CEP90_RS00115 3686..3931 + 246 WP_000356546.1 hypothetical protein -
CEP90_RS00120 3921..4136 + 216 WP_001180117.1 hypothetical protein -
CEP90_RS00125 4229..4558 + 330 WP_000866654.1 hypothetical protein -
CEP90_RS00130 4601..4780 + 180 WP_024135241.1 hypothetical protein -
CEP90_RS27340 4850..5014 + 165 WP_000003881.1 hypothetical protein -
CEP90_RS00135 5011..5283 + 273 WP_000160399.1 hypothetical protein -
CEP90_RS27345 5540..5614 + 75 Protein_11 DNA distortion polypeptide 3 -
CEP90_RS00145 5609..6154 + 546 WP_001426313.1 hypothetical protein -
CEP90_RS00150 6157..7323 + 1167 WP_000539542.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..44561 44561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T78336 WP_000220560.1 NZ_CP022061:2891-3172 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T78336 NZ_CP022061:2891-3172 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT78336 WP_000121743.1 NZ_CP022061:2650-2901 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT78336 NZ_CP022061:2650-2901 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References