Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2206620..2207313 Replicon chromosome
Accession NZ_CP022059
Organism Enterococcus faecalis strain FDAARGOS_338

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag CEQ16_RS11505 Protein ID WP_002381718.1
Coordinates 2206969..2207313 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag CEQ16_RS11500 Protein ID WP_002364355.1
Coordinates 2206620..2206952 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ16_RS11450 2202091..2202825 - 735 WP_002381724.1 ERF family protein -
CEQ16_RS11455 2202818..2203136 - 319 Protein_2091 hypothetical protein -
CEQ16_RS11460 2203356..2203910 + 555 WP_002357006.1 hypothetical protein -
CEQ16_RS11470 2204195..2204531 - 337 Protein_2093 hypothetical protein -
CEQ16_RS11475 2204568..2204777 - 210 WP_002381721.1 hypothetical protein -
CEQ16_RS11480 2204832..2205020 + 189 WP_002357001.1 YegP family protein -
CEQ16_RS11485 2205046..2205771 - 726 WP_002381720.1 phage regulatory protein -
CEQ16_RS11490 2205810..2206121 - 312 WP_002381719.1 hypothetical protein -
CEQ16_RS11495 2206132..2206308 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
CEQ16_RS11500 2206620..2206952 + 333 WP_002364355.1 helix-turn-helix domain-containing protein Antitoxin
CEQ16_RS11505 2206969..2207313 + 345 WP_002381718.1 ImmA/IrrE family metallo-endopeptidase Toxin
CEQ16_RS11510 2207349..2208077 + 729 WP_002381717.1 potassium channel family protein -
CEQ16_RS11515 2208177..2209325 + 1149 WP_002381716.1 site-specific integrase -
CEQ16_RS11520 2209353..2209796 - 444 WP_002381715.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CEQ16_RS11525 2209793..2210068 - 276 WP_002356991.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CEQ16_RS11530 2210068..2211114 - 1047 WP_002356990.1 type II secretion system F family protein -
CEQ16_RS11535 2211071..2212039 - 969 WP_002364362.1 Flp pilus assembly complex ATPase component TadA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2170001..2228175 58174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13784.69 Da        Isoelectric Point: 5.2350

>T78335 WP_002381718.1 NZ_CP022059:2206969-2207313 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDEQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

>T78335 NZ_CP022059:2206969-2207313 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGAGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT78335 WP_002364355.1 NZ_CP022059:2206620-2206952 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT78335 NZ_CP022059:2206620-2206952 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References