Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 165988..166570 Replicon chromosome
Accession NZ_CP022059
Organism Enterococcus faecalis strain FDAARGOS_338

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag CEQ16_RS00900 Protein ID WP_002355414.1
Coordinates 165988..166296 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag CEQ16_RS00905 Protein ID WP_002326825.1
Coordinates 166298..166570 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ16_RS00865 161775..162707 - 933 WP_002363040.1 tagatose-6-phosphate kinase -
CEQ16_RS00870 162718..163233 - 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
CEQ16_RS00875 163250..163675 - 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
CEQ16_RS00885 164163..164930 + 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
CEQ16_RS00890 164935..165435 + 501 WP_002363039.1 HAD family hydrolase -
CEQ16_RS00895 165480..165908 + 429 WP_071623404.1 tyrosine-type recombinase/integrase -
CEQ16_RS00900 165988..166296 - 309 WP_002355414.1 zeta toxin family protein Toxin
CEQ16_RS00905 166298..166570 - 273 WP_002326825.1 antitoxin Antitoxin
CEQ16_RS00910 166587..166796 - 210 WP_002363035.1 peptide-binding protein -
CEQ16_RS00915 166873..167769 - 897 WP_002363034.1 ParA family protein -
CEQ16_RS00920 167844..167966 - 123 Protein_173 topoisomerase -
CEQ16_RS00930 168158..169441 - 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
CEQ16_RS00935 169458..170384 - 927 WP_002355406.1 hypothetical protein -
CEQ16_RS00940 170561..171289 + 729 WP_002355404.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL psaA / esp / bsh 52477..198748 146271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T78310 WP_002355414.1 NZ_CP022059:c166296-165988 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T78310 NZ_CP022059:c166296-165988 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT78310 WP_002326825.1 NZ_CP022059:c166570-166298 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT78310 NZ_CP022059:c166570-166298 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References