Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1545453..1546259 Replicon chromosome
Accession NZ_CP022056
Organism Staphylococcus saprophyticus strain FDAARGOS_336

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag CEQ14_RS07830 Protein ID WP_011302805.1
Coordinates 1546074..1546259 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag CEQ14_RS07825 Protein ID WP_011302804.1
Coordinates 1545453..1546052 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ14_RS07805 1541331..1542794 + 1464 WP_047502301.1 ABC transporter substrate-binding protein/permease -
CEQ14_RS07810 1542787..1543509 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
CEQ14_RS07815 1543670..1544797 + 1128 WP_011302803.1 tRNA epoxyqueuosine(34) reductase QueG -
CEQ14_RS07820 1544802..1545272 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
CEQ14_RS07825 1545453..1546052 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
CEQ14_RS07830 1546074..1546259 + 186 WP_011302805.1 hypothetical protein Toxin
CEQ14_RS07835 1546416..1546832 + 417 WP_011302806.1 hypothetical protein -
CEQ14_RS07840 1547210..1548595 + 1386 WP_011302807.1 class II fumarate hydratase -
CEQ14_RS07845 1548798..1549625 - 828 WP_069795249.1 RluA family pseudouridine synthase -
CEQ14_RS07850 1549810..1550925 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T78309 WP_011302805.1 NZ_CP022056:1546074-1546259 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T78309 NZ_CP022056:1546074-1546259 [Staphylococcus saprophyticus]
ATGAGTTTAGATAAAAATCAAAATAATCTACATCGTGATGAATTAGAGTCAGAAAACGCGATGGTTGATGATTTAGAGGA
TGTCGTAGAATTAGGAAAAGAAATGGAACAAATCTCTGAAGAAAATGATGAAGATAAATTAGATAAATCACATGACCCAG
CAGTACGTTCCGATTTAAATGAATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT78309 WP_011302804.1 NZ_CP022056:1545453-1546052 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT78309 NZ_CP022056:1545453-1546052 [Staphylococcus saprophyticus]
ATGGCAATGAACTTTAAAGTTTTAGAAAATGAACAAGTTGTAGCGGAATATGCTGCAGATATCTTAAGAAAACAATTTAA
CAACAATCCAACAACAATTGCTGGCGTACACCTTTCAAGTGACAATGCACCAGTATTGGATGAATTAAAGAAAAATGTTG
ATAAACATGCAGTAGATTTTAGTCAAATTAATATTCTGGATTATGATAACAATAAATCATACTTTGAAGCACTTGGTGTT
CCAGAAGGCCAAATCTTCAATGTTTCATTTGGTGAAGATACGGAATCATTTATTAAAGATAAAATCAAAACTAAAGAAAA
TAAAGGGAAATTGATTACACAAGTACTTTCTATTGATACAAATGGTAAATTAGATGTAAGTGTGAATCAAGGTTTATTCT
CGGCACGTGAAGTTATTTTAATTATTACAGGTAGCGATAAAAAAGAAGTCGTTCATAAACTTTATGAAGAAAATGGTAAA
ACAAGTTTTGAACCTTCAGATTTAAAAGCGCACCGTATGGTTAATGTTATTTTAGATGAAGCGGCTGCTGAAGGTTTACC
AGAAGATGTTAGACATTATTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References