Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1378271..1378785 Replicon chromosome
Accession NZ_CP022056
Organism Staphylococcus saprophyticus strain FDAARGOS_336

Toxin (Protein)


Gene name TsdT Uniprot ID Q49Z34
Locus tag CEQ14_RS06835 Protein ID WP_011302693.1
Coordinates 1378579..1378785 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag CEQ14_RS06830 Protein ID WP_002482740.1
Coordinates 1378271..1378564 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ14_RS06805 1373433..1374224 + 792 WP_011302688.1 hydroxyethylthiazole kinase -
CEQ14_RS06810 1374224..1374862 + 639 WP_011302689.1 thiamine phosphate synthase -
CEQ14_RS06815 1374950..1375819 + 870 WP_011302690.1 membrane protein insertase YidC -
CEQ14_RS06820 1375901..1376575 - 675 WP_170178158.1 HD domain-containing protein -
CEQ14_RS06825 1376644..1378128 - 1485 WP_011302692.1 cardiolipin synthase -
CEQ14_RS06830 1378271..1378564 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
CEQ14_RS06835 1378579..1378785 + 207 WP_011302693.1 hypothetical protein Toxin
CEQ14_RS06840 1378998..1379138 + 141 WP_002482742.1 hypothetical protein -
CEQ14_RS06845 1379431..1380636 - 1206 WP_011302694.1 rod shape-determining protein RodA -
CEQ14_RS06850 1380885..1381955 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
CEQ14_RS06855 1381968..1383323 + 1356 WP_011302696.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8040.28 Da        Isoelectric Point: 4.3776

>T78307 WP_011302693.1 NZ_CP022056:1378579-1378785 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSTDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T78307 NZ_CP022056:1378579-1378785 [Staphylococcus saprophyticus]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGACTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTACAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT78307 WP_002482740.1 NZ_CP022056:1378271-1378564 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT78307 NZ_CP022056:1378271-1378564 [Staphylococcus saprophyticus]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q49Z34

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References