Detailed information of TA system TA078302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 2762985..2763633
• Replicon: chromosome
• Accession: NZ_CP022053
• Organism: Stenotrophomonas maltophilia strain FDAARGOS_325

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: B2FJ07
• Locus tag: CEQ03_RS13130
• Protein ID: WP_012478870.1
• Coordinates: 2763346..2763633 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: CEQ03_RS13125
• Protein ID: WP_012478871.1
• Coordinates: 2762985..2763287 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ03_RS13090	2757996..2758217	-	222	WP_004153772.1	CsbD family protein	-
CEQ03_RS13095	2758426..2758563	-	138	WP_005407710.1	entericidin A/B family lipoprotein	-
CEQ03_RS13100	2758724..2759644	-	921	WP_005407709.1	arginase	-
CEQ03_RS13105	2759749..2760693	-	945	WP_012478875.1	ankyrin repeat domain-containing protein	-
CEQ03_RS13110	2760753..2761523	-	771	WP_012478874.1	DUF3011 domain-containing protein	-
CEQ03_RS13115	2762117..2762524	+	408	WP_044569408.1	hypothetical protein	-
CEQ03_RS13120	2762604..2762927	+	324	WP_012478872.1	hypothetical protein	-
CEQ03_RS13125	2762985..2763287	-	303	WP_012478871.1	putative addiction module antidote protein	Antitoxin
CEQ03_RS13130	2763346..2763633	-	288	WP_012478870.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ03_RS13135	2763867..2764466	+	600	WP_012478869.1	hypothetical protein	-
CEQ03_RS22820	2764494..2765618	+	1125	WP_012478868.1	hypothetical protein	-
CEQ03_RS13145	2766422..2767750	-	1329	WP_152908586.1	MFS transporter	-
CEQ03_RS13150	2767737..2768327	-	591	WP_049460186.1	hypothetical protein	-
CEQ03_RS23025	2768339..2768497	-	159	WP_160314580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2762985..2772443	9458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10802.42 Da
• Isoelectric Point: 10.8940

>T78302 WP_012478870.1 NZ_CP022053:c2763633-2763346 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T78302 NZ_CP022053:c2763633-2763346 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCGGGTGATCACCGCTATCTGGGGGACGGTATTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCCTGTACTACACCCAGCGCGGCAGGCAGTTGCTGATTCTTTTGGTCGGAGGTGACAAAAGCTCA
CAGCAACGCGATATCGAAAAGGCCAGGGAGATTGCACGTGCCCTGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10738.32 Da
• Isoelectric Point: 8.0343

>AT78302 WP_012478871.1 NZ_CP022053:c2763287-2762985 [Stenotrophomonas maltophilia]
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Nucleotide

• Length: 303 bp

>AT78302 NZ_CP022053:c2763287-2762985 [Stenotrophomonas maltophilia]
ATGGCCACTAAGAAAAAAGTCGAACTCAAATCATTTGATGTGGCCGAACACCTTCGGACACCCGAAGAAATGGCAGCCTA
TCTCGACGCCTGCATCGAGGAAAGCGACGGCGATTCCGCGTTCATCGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GTATGAGCAAGGTTGCGCGCGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCTTGGGTGTGCGCCTGCATGCCAGTGCCGTGTGA

Structures

Toxin

• AlphaFold DB: A0A854E218