Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4466921..4467716 Replicon chromosome
Accession NZ_CP022050
Organism Escherichia coli O157 strain FDAARGOS_293

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag CEP72_RS23325 Protein ID WP_000854914.1
Coordinates 4467342..4467716 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag CEP72_RS23320 Protein ID WP_001280954.1
Coordinates 4466921..4467295 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP72_RS23280 4462276..4463181 + 906 WP_000203541.1 chemotaxis protein -
CEP72_RS23285 4463178..4464248 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
CEP72_RS23300 4464588..4465406 + 819 WP_001234682.1 DUF945 domain-containing protein -
CEP72_RS23305 4465497..4465982 + 486 WP_000214398.1 antirestriction protein -
CEP72_RS23310 4465998..4466474 + 477 WP_001186738.1 RadC family protein -
CEP72_RS23315 4466537..4466758 + 222 WP_001220314.1 DUF987 domain-containing protein -
CEP72_RS23320 4466921..4467295 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEP72_RS23325 4467342..4467716 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
CEP72_RS23330 4467713..4468204 + 492 WP_000976853.1 hypothetical protein -
CEP72_RS23335 4468216..4468413 + 198 WP_000839282.1 DUF957 domain-containing protein -
CEP72_RS23340 4468498..4469340 + 843 WP_001280481.1 DUF4942 domain-containing protein -
CEP72_RS23350 4469811..4470749 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
CEP72_RS23355 4470804..4471541 + 738 WP_000283664.1 zinc-binding phosphatase -
CEP72_RS23360 4471565..4472119 + 555 WP_001001917.1 molecular chaperone YcdY -
CEP72_RS23365 4472221..4472712 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T78283 WP_000854914.1 NZ_CP022050:4467342-4467716 [Escherichia coli O157]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T78283 NZ_CP022050:4467342-4467716 [Escherichia coli O157]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT78283 WP_001280954.1 NZ_CP022050:4466921-4467295 [Escherichia coli O157]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT78283 NZ_CP022050:4466921-4467295 [Escherichia coli O157]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References