Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 498206..498684 Replicon chromosome
Accession NZ_CP022050
Organism Escherichia coli O157 strain FDAARGOS_293

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag CEP72_RS03010 Protein ID WP_001303876.1
Coordinates 498397..498684 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag CEP72_RS03005 Protein ID WP_000536233.1
Coordinates 498206..498397 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP72_RS02970 493610..494380 - 771 WP_000450992.1 DUF1627 domain-containing protein -
CEP72_RS02975 494402..495148 - 747 WP_000788751.1 ATP-binding protein -
CEP72_RS02980 495155..496246 - 1092 WP_001205823.1 hypothetical protein -
CEP72_RS02985 496325..496780 + 456 WP_000273724.1 hypothetical protein -
CEP72_RS02990 496987..497412 - 426 WP_000693855.1 Rha family transcriptional regulator -
CEP72_RS02995 497396..497668 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
CEP72_RS03000 497777..498178 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
CEP72_RS03005 498206..498397 + 192 WP_000536233.1 hypothetical protein Antitoxin
CEP72_RS03010 498397..498684 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEP72_RS03020 498962..499117 + 156 WP_000379575.1 DUF1391 family protein -
CEP72_RS03030 499259..499648 + 390 WP_000394511.1 hypothetical protein -
CEP72_RS03035 499835..500020 - 186 WP_001133046.1 hypothetical protein -
CEP72_RS03045 500594..500782 + 189 WP_000413705.1 cell division inhibition protein DicB -
CEP72_RS03050 500779..500970 + 192 WP_001098307.1 DUF1482 family protein -
CEP72_RS03055 501064..501693 + 630 Protein_543 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T78264 WP_001303876.1 NZ_CP022050:498397-498684 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T78264 NZ_CP022050:498397-498684 [Escherichia coli O157]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT78264 WP_000536233.1 NZ_CP022050:498206-498397 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT78264 NZ_CP022050:498206-498397 [Escherichia coli O157]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References