Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 498206..498684 | Replicon | chromosome |
Accession | NZ_CP022050 | ||
Organism | Escherichia coli O157 strain FDAARGOS_293 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A891SFN9 |
Locus tag | CEP72_RS03010 | Protein ID | WP_001303876.1 |
Coordinates | 498397..498684 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XD67 |
Locus tag | CEP72_RS03005 | Protein ID | WP_000536233.1 |
Coordinates | 498206..498397 (+) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CEP72_RS02970 | 493610..494380 | - | 771 | WP_000450992.1 | DUF1627 domain-containing protein | - |
CEP72_RS02975 | 494402..495148 | - | 747 | WP_000788751.1 | ATP-binding protein | - |
CEP72_RS02980 | 495155..496246 | - | 1092 | WP_001205823.1 | hypothetical protein | - |
CEP72_RS02985 | 496325..496780 | + | 456 | WP_000273724.1 | hypothetical protein | - |
CEP72_RS02990 | 496987..497412 | - | 426 | WP_000693855.1 | Rha family transcriptional regulator | - |
CEP72_RS02995 | 497396..497668 | - | 273 | WP_000887453.1 | helix-turn-helix domain-containing protein | - |
CEP72_RS03000 | 497777..498178 | + | 402 | WP_000986592.1 | helix-turn-helix domain-containing protein | - |
CEP72_RS03005 | 498206..498397 | + | 192 | WP_000536233.1 | hypothetical protein | Antitoxin |
CEP72_RS03010 | 498397..498684 | + | 288 | WP_001303876.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CEP72_RS03020 | 498962..499117 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
CEP72_RS03030 | 499259..499648 | + | 390 | WP_000394511.1 | hypothetical protein | - |
CEP72_RS03035 | 499835..500020 | - | 186 | WP_001133046.1 | hypothetical protein | - |
CEP72_RS03045 | 500594..500782 | + | 189 | WP_000413705.1 | cell division inhibition protein DicB | - |
CEP72_RS03050 | 500779..500970 | + | 192 | WP_001098307.1 | DUF1482 family protein | - |
CEP72_RS03055 | 501064..501693 | + | 630 | Protein_543 | exonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10978.84 Da Isoelectric Point: 10.1360
>T78264 WP_001303876.1 NZ_CP022050:498397-498684 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
Download Length: 288 bp
>T78264 NZ_CP022050:498397-498684 [Escherichia coli O157]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7025.80 Da Isoelectric Point: 4.0270
>AT78264 WP_000536233.1 NZ_CP022050:498206-498397 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
Download Length: 192 bp
>AT78264 NZ_CP022050:498206-498397 [Escherichia coli O157]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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