Detailed information of TA system TA078242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3298835..3299354
• Replicon: chromosome
• Accession: NZ_CP022049
• Organism: Citrobacter braakii strain FDAARGOS_290

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEP69_RS16255
• Protein ID: WP_016155559.1
• Coordinates: 3299073..3299354 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0V9JX71
• Locus tag: CEP69_RS16250
• Protein ID: WP_016155558.1
• Coordinates: 3298835..3299083 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP69_RS16235	3294585..3295532	+	948	WP_016155554.1	type VI secretion system baseplate subunit TssG	-
CEP69_RS16240	3295523..3298024	+	2502	WP_016155555.1	type VI secretion system ATPase TssH	-
CEP69_RS16245	3298067..3298540	+	474	WP_016155556.1	hypothetical protein	-
CEP69_RS16250	3298835..3299083	+	249	WP_016155558.1	hypothetical protein	Antitoxin
CEP69_RS16255	3299073..3299354	+	282	WP_016155559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEP69_RS16260	3299382..3301346	+	1965	WP_016155560.1	type VI secretion system tip protein VgrG	-
CEP69_RS16265	3301346..3301867	+	522	WP_016155561.1	hypothetical protein	-
CEP69_RS16270	3301886..3302350	-	465	WP_016155562.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11004.76 Da
• Isoelectric Point: 10.4466

>T78242 WP_016155559.1 NZ_CP022049:3299073-3299354 [Citrobacter braakii]
MTYNLEFLDVALKEWRKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Nucleotide

• Length: 282 bp

>T78242 NZ_CP022049:3299073-3299354 [Citrobacter braakii]
ATGACCTATAACCTGGAGTTTTTAGATGTTGCGCTCAAGGAGTGGCGCAAGCTTTCACCCACATTACGCGAGCAGTTCAA
AAAGAAACTGGCGGAGCGGCTGGAAAATCCCCATGTCCCTGCCGCCCGCCTTTCCGGCAAATTACACCGTTACAAAATCA
AGCTTCGCAGTGCCGGGTATCGTCTGGTCTATCAGGTCGAGGACGAGCAGGTTGTCGTTCTTGTGATCGCAGTGGGCAGA
CGTGATGGTGATGAGGTTTATCATCAGGCTAACCGGCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 4.7513

>AT78242 WP_016155558.1 NZ_CP022049:3298835-3299083 [Citrobacter braakii]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIKVSLN
DL

Nucleotide

• Length: 249 bp

>AT78242 NZ_CP022049:3298835-3299083 [Citrobacter braakii]
ATGCCATTTCATATCCTGACCAAAACCGCTGCCAGTATCACCGACCTGAAACGTAACCCAATGGGGACAGTCAACGCCGG
GGAAGGTGAAGCGGTGGCGATTCTGAACCGCAATGAGCCTGCGTTTTACTGCGTGCCGCCTGCGGTCTATGCATATTTGC
TGGAGCTGGCTGAGGATGCCGAGCTGAACCGCATCGCCGACGAGCGAGAAGGTGGAAAGCGAATAAAGGTATCTTTAAAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0V9JX71