Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2863797..2864413 | Replicon | chromosome |
Accession | NZ_CP022049 | ||
Organism | Citrobacter braakii strain FDAARGOS_290 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | CEP69_RS14180 | Protein ID | WP_016155182.1 |
Coordinates | 2864039..2864413 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | R8WIS4 |
Locus tag | CEP69_RS14175 | Protein ID | WP_016155181.1 |
Coordinates | 2863797..2864039 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CEP69_RS14140 | 2859205..2859804 | + | 600 | WP_016157873.1 | glucose-1-phosphatase | - |
CEP69_RS14145 | 2859798..2860670 | + | 873 | WP_019077938.1 | virulence factor BrkB family protein | - |
CEP69_RS14150 | 2860667..2861104 | + | 438 | WP_016157874.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
CEP69_RS14155 | 2861149..2862090 | + | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
CEP69_RS14160 | 2862096..2862383 | - | 288 | WP_016157876.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
CEP69_RS14165 | 2862376..2862618 | - | 243 | WP_016155179.1 | type II toxin-antitoxin system ParD family antitoxin | - |
CEP69_RS14170 | 2862683..2863591 | - | 909 | Protein_2674 | alpha/beta hydrolase | - |
CEP69_RS14175 | 2863797..2864039 | + | 243 | WP_016155181.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
CEP69_RS14180 | 2864039..2864413 | + | 375 | WP_016155182.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
CEP69_RS14185 | 2864450..2865379 | - | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
CEP69_RS14190 | 2865376..2866011 | - | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
CEP69_RS14195 | 2866008..2866910 | - | 903 | WP_003028691.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2851348..2864413 | 13065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13678.84 Da Isoelectric Point: 8.5373
>T78241 WP_016155182.1 NZ_CP022049:2864039-2864413 [Citrobacter braakii]
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL
Download Length: 375 bp
>T78241 NZ_CP022049:2864039-2864413 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTGATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGAGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTGATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGAGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9437.72 Da Isoelectric Point: 4.3331
>AT78241 WP_016155181.1 NZ_CP022049:2863797-2864039 [Citrobacter braakii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW
Download Length: 243 bp
>AT78241 NZ_CP022049:2863797-2864039 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCTGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGCGAGGAATGG
TAA
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCTGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGCGAGGAATGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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