Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-RelB
Location 2290236..2290744 Replicon chromosome
Accession NZ_CP022048
Organism Brevundimonas vesicularis strain FDAARGOS_289

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4P8QC21
Locus tag CEP68_RS28675 Protein ID WP_066626960.1
Coordinates 2290236..2290490 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A4P8QCA2
Locus tag CEP68_RS28680 Protein ID WP_066626962.1
Coordinates 2290487..2290744 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP68_RS28650 2285288..2285542 - 255 WP_066626951.1 type II toxin-antitoxin system ParD family antitoxin -
CEP68_RS28655 2285597..2287168 - 1572 WP_088582690.1 response regulator -
CEP68_RS28660 2287281..2288018 + 738 WP_088582691.1 hypothetical protein -
CEP68_RS28665 2288015..2289376 - 1362 WP_066626956.1 glutamate--cysteine ligase -
CEP68_RS28670 2289512..2290231 - 720 WP_066626959.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
CEP68_RS28675 2290236..2290490 - 255 WP_066626960.1 Txe/YoeB family addiction module toxin Toxin
CEP68_RS28680 2290487..2290744 - 258 WP_066626962.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CEP68_RS28685 2290798..2291961 - 1164 WP_066626964.1 acyl-CoA dehydrogenase family protein -
CEP68_RS28690 2292026..2292406 + 381 WP_066626969.1 hypothetical protein -
CEP68_RS28695 2292407..2294191 - 1785 WP_066626971.1 acyl-CoA dehydrogenase C-terminal domain-containing protein -
CEP68_RS28700 2294195..2294677 - 483 WP_039244783.1 MerR family DNA-binding transcriptional regulator -
CEP68_RS28705 2294868..2295284 - 417 WP_066626973.1 DoxX family protein -
CEP68_RS28710 2295495..2295713 - 219 WP_039244779.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9946.37 Da        Isoelectric Point: 9.9687

>T78237 WP_066626960.1 NZ_CP022048:c2290490-2290236 [Brevundimonas vesicularis]
MNVLFTARAWSQYTEWQDTDRKALKKLNTLIKECQRTPFTGSGKPEPLKGELAGFWSRRIDQEHRLVYRATQTGLEIVQC
RFHY

Download         Length: 255 bp

>T78237 NZ_CP022048:c2290490-2290236 [Brevundimonas vesicularis]
ATGAACGTCCTCTTCACGGCCCGCGCCTGGTCTCAATATACCGAGTGGCAGGATACGGACCGCAAAGCGCTCAAGAAGCT
GAACACGCTCATCAAGGAATGCCAACGAACCCCGTTTACAGGCTCCGGCAAGCCCGAGCCATTGAAGGGTGAATTGGCGG
GATTTTGGTCGCGACGTATCGATCAGGAGCATCGCCTAGTCTATCGCGCGACCCAGACCGGCTTGGAAATCGTCCAATGC
CGCTTTCACTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9364.50 Da        Isoelectric Point: 4.3566

>AT78237 WP_066626962.1 NZ_CP022048:c2290744-2290487 [Brevundimonas vesicularis]
MNAMSVTDLRKNLASAIDRVTADHDYTIITREGGKPAAVLMSLEDFASWQETEYLLRSPANREALRASIAELEAGGGQVR
ELIEE

Download         Length: 258 bp

>AT78237 NZ_CP022048:c2290744-2290487 [Brevundimonas vesicularis]
ATGAACGCGATGTCCGTCACCGATCTCCGCAAGAACCTCGCCTCGGCCATCGACCGGGTGACGGCGGATCATGACTACAC
CATCATCACGCGCGAGGGCGGTAAGCCGGCGGCGGTGCTGATGTCGCTGGAGGACTTCGCCTCGTGGCAGGAGACGGAGT
ATCTGCTGCGCAGCCCGGCCAACCGCGAAGCGCTGCGAGCCTCGATTGCCGAACTTGAAGCGGGTGGCGGCCAGGTGCGC
GAACTGATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8QC21

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8QCA2

References