Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 2284980..2285542 Replicon chromosome
Accession NZ_CP022048
Organism Brevundimonas vesicularis strain FDAARGOS_289

Toxin (Protein)


Gene name parE Uniprot ID A0A1Z3UA13
Locus tag CEP68_RS28645 Protein ID WP_066626950.1
Coordinates 2284980..2285291 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3UA07
Locus tag CEP68_RS28650 Protein ID WP_066626951.1
Coordinates 2285288..2285542 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP68_RS28620 2280683..2281411 + 729 WP_066626946.1 hydroxyacylglutathione hydrolase -
CEP68_RS28625 2281408..2282175 - 768 WP_066626947.1 DUF4908 domain-containing protein -
CEP68_RS28630 2282225..2282950 - 726 WP_039244832.1 acetoacetyl-CoA reductase -
CEP68_RS28635 2283095..2284150 - 1056 WP_174523852.1 NAD(P)-dependent alcohol dehydrogenase -
CEP68_RS28640 2284234..2284983 - 750 WP_066626948.1 DUF72 domain-containing protein -
CEP68_RS28645 2284980..2285291 - 312 WP_066626950.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEP68_RS28650 2285288..2285542 - 255 WP_066626951.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CEP68_RS28655 2285597..2287168 - 1572 WP_088582690.1 response regulator -
CEP68_RS28660 2287281..2288018 + 738 WP_088582691.1 hypothetical protein -
CEP68_RS28665 2288015..2289376 - 1362 WP_066626956.1 glutamate--cysteine ligase -
CEP68_RS28670 2289512..2290231 - 720 WP_066626959.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
CEP68_RS28675 2290236..2290490 - 255 WP_066626960.1 Txe/YoeB family addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11867.19 Da        Isoelectric Point: 5.5447

>T78236 WP_066626950.1 NZ_CP022048:c2285291-2284980 [Brevundimonas vesicularis]
MSGYRLSKEASEDLVAIYIQGHDQFGPRQADRYQDELDALFRRLAASPGMARLRLEYDPPIRVFAFKAHVIVYDQEHDGV
LIQRVRHGHEDWQGATGDERSEP

Download         Length: 312 bp

>T78236 NZ_CP022048:c2285291-2284980 [Brevundimonas vesicularis]
ATGAGCGGCTATCGCTTGTCGAAGGAGGCGAGCGAGGATCTCGTCGCCATCTATATTCAGGGTCACGACCAGTTCGGTCC
GCGACAGGCCGACCGCTATCAGGACGAACTCGACGCCCTGTTTCGGCGGTTGGCGGCCTCTCCCGGGATGGCCCGACTGC
GTCTGGAATACGATCCGCCCATCCGCGTGTTCGCCTTCAAGGCTCATGTGATAGTCTACGATCAGGAACATGACGGCGTC
CTCATCCAGCGGGTTCGTCACGGACACGAGGATTGGCAAGGCGCGACCGGCGACGAACGGAGCGAACCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9433.85 Da        Isoelectric Point: 10.3437

>AT78236 WP_066626951.1 NZ_CP022048:c2285542-2285288 [Brevundimonas vesicularis]
MATMNISLPDPMKAWVEEQAKSGRYANTSDVVRDLIRREQVKAEKIANMQRLIDEGRASGISEMTMADIRAEALSRIAQR
RKAG

Download         Length: 255 bp

>AT78236 NZ_CP022048:c2285542-2285288 [Brevundimonas vesicularis]
ATGGCGACGATGAACATCTCCCTGCCCGATCCCATGAAGGCCTGGGTTGAGGAACAGGCGAAATCCGGGCGCTACGCCAA
CACGTCGGACGTGGTGCGCGACCTGATCCGCCGCGAGCAGGTCAAGGCTGAGAAGATCGCCAACATGCAGCGCCTGATCG
ATGAAGGCCGGGCCAGCGGGATCAGCGAGATGACCATGGCGGATATTCGCGCCGAGGCCCTGTCCCGCATCGCCCAGCGG
CGTAAGGCTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3UA13

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3UA07

References