Detailed information of TA system TA078235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2180930..2181594
• Replicon: chromosome
• Accession: NZ_CP022048
• Organism: Brevundimonas vesicularis strain FDAARGOS_289

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1H1DI79
• Locus tag: CEP68_RS28100
• Protein ID: WP_066626804.1
• Coordinates: 2180930..2181364 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CEP68_RS28105
• Protein ID: WP_088582677.1
• Coordinates: 2181361..2181594 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP68_RS28065	2176538..2176915	+	378	WP_205678467.1	hypothetical protein	-
CEP68_RS28070	2176912..2177775	+	864	WP_066626798.1	hypothetical protein	-
CEP68_RS28075	2177781..2178239	+	459	WP_066626997.1	tol-pal system-associated acyl-CoA thioesterase	-
CEP68_RS28080	2178265..2178699	+	435	WP_066626800.1	hypothetical protein	-
CEP68_RS28085	2178840..2179592	+	753	WP_055753946.1	protein TolQ	-
CEP68_RS28090	2179596..2180048	+	453	WP_066626802.1	ExbD/TolR family protein	-
CEP68_RS34245	2180054..2180926	+	873	WP_088582676.1	cell envelope integrity protein TolA	-
CEP68_RS28100	2180930..2181364	-	435	WP_066626804.1	DNA-binding protein	Toxin
CEP68_RS28105	2181361..2181594	-	234	WP_088582677.1	CopG family transcriptional regulator	Antitoxin
CEP68_RS28110	2181736..2183100	+	1365	WP_066626809.1	Tol-Pal system protein TolB	-
CEP68_RS28115	2183241..2183804	+	564	WP_066626810.1	peptidoglycan-associated lipoprotein Pal	-
CEP68_RS28120	2183932..2185074	+	1143	WP_066626812.1	DUF3667 domain-containing protein	-
CEP68_RS28125	2185116..2185961	+	846	WP_066554439.1	tol-pal system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15381.65 Da
• Isoelectric Point: 6.6004

>T78235 WP_066626804.1 NZ_CP022048:c2181364-2180930 [Brevundimonas vesicularis]
MIALLDVSVLIALIDPAHTEHLTAHAWFANEHQAGWATCPLTENGALRILSNPKYPNSPGAPAQVLPALHSLLSQPGHVF
WPDDISLLSDRLIAQDRLLTSGQLTDTYLLALAVSNGGRLATFDRRLAPDAVKGGKAALHLITA

Nucleotide

• Length: 435 bp

>T78235 NZ_CP022048:c2181364-2180930 [Brevundimonas vesicularis]
TTGATCGCGCTTTTGGACGTCAGCGTCCTGATCGCATTGATCGATCCAGCCCATACCGAGCATCTCACCGCCCACGCCTG
GTTCGCAAATGAGCATCAGGCTGGTTGGGCGACCTGCCCGCTGACCGAAAACGGCGCGCTTCGAATCCTCAGCAATCCGA
AGTATCCAAACTCGCCGGGCGCGCCTGCGCAGGTGTTGCCCGCGCTTCATTCCTTGCTGAGCCAACCCGGCCATGTGTTC
TGGCCCGACGACATCAGTCTGCTGAGCGACCGTTTGATCGCGCAGGATCGCCTGCTCACCTCGGGCCAGTTGACGGATAC
CTATCTGCTGGCCTTAGCCGTATCGAACGGCGGGCGGCTGGCCACGTTCGACCGACGCCTGGCGCCCGACGCGGTGAAGG
GCGGCAAGGCGGCCCTACATCTCATAACGGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8493.65 Da
• Isoelectric Point: 9.1311

>AT78235 WP_088582677.1 NZ_CP022048:c2181594-2181361 [Brevundimonas vesicularis]
MRTTLAIDEDVLNAARAIAVQTRTSVGEVISDLARRSITQARPDTSPEFRNGIRLLPHRKGAVVTTEQINALRDELP

Nucleotide

• Length: 234 bp

>AT78235 NZ_CP022048:c2181594-2181361 [Brevundimonas vesicularis]
ATGCGCACTACACTCGCCATCGACGAAGACGTGCTGAACGCCGCACGGGCCATCGCGGTTCAGACCCGAACCTCTGTGGG
CGAAGTCATTTCCGATCTCGCGCGCCGCTCGATCACACAGGCCAGGCCGGACACGTCGCCCGAGTTCCGCAACGGCATTC
GTCTCCTGCCGCACCGCAAGGGCGCTGTGGTGACGACCGAACAGATCAACGCTCTGCGCGATGAGCTGCCTTGA

Structures

Toxin

• AlphaFold DB: A0A1H1DI79