Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3041343..3041985 Replicon chromosome
Accession NZ_CP022044
Organism Bacillus anthracis strain FDAARGOS_341

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag CEQ19_RS17095 Protein ID WP_000635963.1
Coordinates 3041635..3041985 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag CEQ19_RS17090 Protein ID WP_000004570.1
Coordinates 3041343..3041630 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ19_RS17065 3036659..3037621 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
CEQ19_RS17070 3037614..3038186 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
CEQ19_RS17075 3038279..3038638 + 360 WP_000635040.1 holo-ACP synthase -
CEQ19_RS17080 3038795..3039745 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
CEQ19_RS17085 3039864..3041033 + 1170 WP_000390596.1 alanine racemase -
CEQ19_RS17090 3041343..3041630 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
CEQ19_RS17095 3041635..3041985 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CEQ19_RS17100 3042053..3044221 + 2169 WP_000426225.1 RNA-binding transcriptional accessory protein -
CEQ19_RS17105 3044279..3044395 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
CEQ19_RS17110 3044591..3045049 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T78231 WP_000635963.1 NZ_CP022044:3041635-3041985 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T78231 NZ_CP022044:3041635-3041985 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT78231 WP_000004570.1 NZ_CP022044:3041343-3041630 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT78231 NZ_CP022044:3041343-3041630 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References