Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 45782..46310 Replicon chromosome
Accession NZ_CP022043
Organism Psychrobacter cryohalolentis strain FDAARGOS_308

Toxin (Protein)


Gene name relE Uniprot ID Q1QBQ3
Locus tag CEP87_RS00430 Protein ID WP_010198775.1
Coordinates 45782..46069 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q1QBQ2
Locus tag CEP87_RS00435 Protein ID WP_011513456.1
Coordinates 46059..46310 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP87_RS00405 41127..41945 - 819 WP_011513451.1 Nif3-like dinuclear metal center hexameric protein -
CEP87_RS00410 42205..43533 + 1329 WP_011513452.1 trypsin-like peptidase domain-containing protein -
CEP87_RS00415 43658..43924 - 267 WP_011513453.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
CEP87_RS00420 44122..45255 - 1134 WP_011513454.1 ribonucleotide-diphosphate reductase subunit beta -
CEP87_RS00425 45328..45711 - 384 WP_011513455.1 hypothetical protein -
CEP87_RS00430 45782..46069 - 288 WP_010198775.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CEP87_RS00435 46059..46310 - 252 WP_011513456.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CEP87_RS00440 46492..47247 - 756 WP_192941317.1 DUF4145 domain-containing protein -
CEP87_RS00445 47450..49726 - 2277 WP_011513458.1 ribonucleoside-diphosphate reductase subunit alpha -
CEP87_RS00450 50289..50594 - 306 WP_188004056.1 DUF493 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-72)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11081.92 Da        Isoelectric Point: 10.5715

>T78230 WP_010198775.1 NZ_CP022043:c46069-45782 [Psychrobacter cryohalolentis]
MTYNLEFHPLALKEWKKIAPNIQQQFKKKLQQRLSNPHVPASKLSGHTDTYKIKLRTVGYRLVYTVKDDVVVVYVLAVGK
RENNKVYDNLATRQP

Download         Length: 288 bp

>T78230 NZ_CP022043:c46069-45782 [Psychrobacter cryohalolentis]
ATGACTTATAATCTTGAGTTTCATCCTTTAGCGTTAAAAGAGTGGAAAAAGATAGCGCCAAATATTCAGCAGCAGTTCAA
GAAAAAATTACAGCAGCGATTGTCAAACCCTCATGTGCCTGCGTCAAAACTATCGGGACATACGGATACTTATAAAATCA
AATTACGCACCGTAGGCTATCGTCTGGTATATACCGTAAAAGATGATGTGGTGGTAGTTTATGTATTAGCAGTAGGCAAA
AGAGAAAACAACAAAGTATATGACAATCTTGCGACACGCCAGCCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9066.40 Da        Isoelectric Point: 4.4278

>AT78230 WP_011513456.1 NZ_CP022043:c46310-46059 [Psychrobacter cryohalolentis]
MKPIFATQTASISELKSNPSALIKQSDGESIAILNHNKPVAYLVSTDVFERMMEAMDDMALSQTVSARLNDGQIPIKVTL
DDL

Download         Length: 252 bp

>AT78230 NZ_CP022043:c46310-46059 [Psychrobacter cryohalolentis]
ATGAAACCAATATTTGCGACACAGACAGCCAGTATCTCAGAACTAAAATCCAACCCGTCGGCACTGATTAAACAGTCAGA
CGGTGAGTCTATTGCTATTTTAAACCACAATAAACCCGTGGCTTACCTAGTTTCGACAGACGTATTCGAGCGCATGATGG
AAGCCATGGACGACATGGCATTAAGCCAAACCGTTAGCGCACGGTTAAATGACGGGCAGATACCGATAAAGGTAACGTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q9ZX66

Antitoxin

Source ID Structure
AlphaFold DB Q1QBQ2

References