Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) brnT-relB/BrnT-RelB
Location 22830..23170 Replicon plasmid unnamed1
Accession NZ_CP022042
Organism Psychrobacter cryohalolentis strain FDAARGOS_308

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag CEP87_RS00130 Protein ID WP_011512349.1
Coordinates 22830..22973 (-) Length 48 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7W2MYR8
Locus tag CEP87_RS00135 Protein ID WP_011512369.1
Coordinates 22970..23170 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP87_RS00100 18016..18825 + 810 WP_011512343.1 hypothetical protein -
CEP87_RS00105 19035..19670 + 636 WP_011512344.1 AAA family ATPase -
CEP87_RS00110 19683..19886 + 204 WP_041753792.1 hypothetical protein -
CEP87_RS00115 20144..21154 + 1011 WP_011512346.1 AAA family ATPase -
CEP87_RS00120 21160..22146 + 987 WP_011512347.1 DUF4435 domain-containing protein -
CEP87_RS00125 22306..22602 - 297 WP_041753794.1 hypothetical protein -
CEP87_RS00130 22830..22973 - 144 WP_011512349.1 BrnT family toxin Toxin
CEP87_RS00135 22970..23170 - 201 WP_011512369.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CEP87_RS00140 23272..23532 - 261 WP_011512370.1 hypothetical protein -
CEP87_RS00145 23600..24001 - 402 WP_011512350.1 hypothetical protein -
CEP87_RS00150 24463..24837 + 375 WP_011512351.1 hypothetical protein -
CEP87_RS00155 25479..26426 + 948 WP_011512352.1 replication initiation protein RepM -
CEP87_RS00160 26586..27713 + 1128 WP_011512353.1 DUF262 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..41221 41221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-47)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-54)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5780.34 Da        Isoelectric Point: 4.4963

>T78229 WP_011512349.1 NZ_CP022042:c22973-22830 [Psychrobacter cryohalolentis]
MIEFEWDEQKNSSNQRKHGLCFEEAARVFFDPLCLRQQDRYENGEER

Download         Length: 144 bp

>T78229 NZ_CP022042:c22973-22830 [Psychrobacter cryohalolentis]
ATGATTGAATTTGAATGGGATGAACAGAAAAATAGCAGTAATCAACGCAAACATGGCTTATGCTTTGAAGAAGCAGCTCG
GGTATTTTTTGATCCTTTGTGTTTGCGTCAACAAGACCGATATGAAAACGGTGAAGAGCGGTAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7427.25 Da        Isoelectric Point: 4.1313

>AT78229 WP_011512369.1 NZ_CP022042:c23170-22970 [Psychrobacter cryohalolentis]
MSTTNYNIRLDQELKDKAFSVLEGYGLTPSQAIKLFLHQVAETNSIPLSFDYQTMPSTNTLEDGDQ

Download         Length: 201 bp

>AT78229 NZ_CP022042:c23170-22970 [Psychrobacter cryohalolentis]
ATGAGCACAACCAATTATAATATCCGTCTCGATCAAGAATTAAAAGACAAGGCGTTTTCGGTGCTTGAAGGCTATGGTTT
AACGCCTTCTCAGGCGATTAAGTTATTTTTGCATCAGGTAGCAGAAACCAATAGCATACCGCTGTCTTTTGATTACCAGA
CAATGCCTAGTACCAATACGCTTGAAGACGGTGATCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2MYR8

References