Detailed information of TA system TA078224

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 89811..90346
• Replicon: plasmid punamed2
• Accession: NZ_CP022035
• Organism: Salmonella enterica subsp. enterica serovar Onderstepoort str. SA20060086

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3W3C6
• Locus tag: LFZ35_RS25065
• Protein ID: WP_015062691.1
• Coordinates: 89811..90098 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3W3C5
• Locus tag: LFZ35_RS25070
• Protein ID: WP_015062690.1
• Coordinates: 90095..90346 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ35_RS25025	85571..85789	+	219	WP_015062698.1	type II toxin-antitoxin system antitoxin CcdA	-
LFZ35_RS25030	85791..86096	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	-
LFZ35_RS25035	86098..86388	+	291	WP_001266176.1	hypothetical protein	-
LFZ35_RS25040	86385..86911	+	527	Protein_87	cytoplasmic protein	-
LFZ35_RS25045	86924..87706	+	783	WP_015062695.1	site-specific integrase	-
LFZ35_RS25050	87857..88786	-	930	WP_015062694.1	Rpn family recombination-promoting nuclease/putative transposase	-
LFZ35_RS25055	89233..89523	-	291	WP_088546700.1	hypothetical protein	-
LFZ35_RS25060	89531..89797	-	267	WP_001749326.1	hypothetical protein	-
LFZ35_RS25065	89811..90098	-	288	WP_015062691.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LFZ35_RS25070	90095..90346	-	252	WP_015062690.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LFZ35_RS25075	90535..90765	-	231	WP_015062689.1	hypothetical protein	-
LFZ35_RS25080	90859..91050	-	192	WP_015062688.1	hypothetical protein	-
LFZ35_RS25090	91789..92655	+	867	WP_015062685.1	AAA family ATPase	-
LFZ35_RS25095	92655..93686	+	1032	WP_015062684.1	ParB/RepB/Spo0J family partition protein	-
LFZ35_RS25100	93686..94123	+	438	WP_088546702.1	hypothetical protein	-
LFZ35_RS26350	94120..94443	+	324	WP_015062682.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..136771	136771

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 14146.97 Da
• Isoelectric Point: 5.5500

>T78224 WP_015062691.1 NZ_CP022035:c90098-89811 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFF

Nucleotide

• Length: 288 bp

>T78224 NZ_CP022035:c90098-89811 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT78224 WP_015062690.1 NZ_CP022035:c90346-90095 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT78224 NZ_CP022035:c90346-90095 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
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Structures

Toxin

• AlphaFold DB: I3W3C6

Antitoxin

• AlphaFold DB: I3W3C5