Detailed information of TA system TA078221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 6694..7319
• Replicon: plasmid punamed2
• Accession: NZ_CP022035
• Organism: Salmonella enterica subsp. enterica serovar Onderstepoort str. SA20060086

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: I3W354
• Locus tag: LFZ35_RS24615
• Protein ID: WP_015062629.1
• Coordinates: 6694..7092 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I3W353
• Locus tag: LFZ35_RS24620
• Protein ID: WP_015062628.1
• Coordinates: 7092..7319 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ35_RS24605	5323..5889	+	567	WP_015062631.1	DUF2726 domain-containing protein	-
LFZ35_RS24610	5886..6617	+	732	WP_015062630.1	type-F conjugative transfer system pilin acetylase TraX	-
LFZ35_RS24615	6694..7092	-	399	WP_015062629.1	tRNA(fMet)-specific endonuclease VapC	Toxin
LFZ35_RS24620	7092..7319	-	228	WP_015062628.1	toxin-antitoxin system antitoxin VapB	Antitoxin
LFZ35_RS24625	7534..8097	+	564	WP_015062627.1	phospholipase D family protein	-
LFZ35_RS24630	8228..8488	+	261	WP_088546681.1	replication regulatory protein RepA	-
LFZ35_RS24635	8716..8793	+	78	WP_032489431.1	RepA leader peptide Tap	-
LFZ35_RS24640	8774..9667	+	894	WP_088546682.1	incFII family plasmid replication initiator RepA	-
LFZ35_RS24650	10647..12266	+	1620	WP_088546684.1	ISL3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..136771	136771

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T78221 WP_015062629.1 NZ_CP022035:c7092-6694 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T78221 NZ_CP022035:c7092-6694 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
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Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 11203.44 Da
• Isoelectric Point: 5.5500

>AT78221 WP_015062628.1 NZ_CP022035:c7319-7092 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 228 bp

>AT78221 NZ_CP022035:c7319-7092 [Salmonella enterica subsp. enterica serovar Onderstepoort str.]
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Structures

Toxin

• AlphaFold DB: I3W354

Antitoxin

• AlphaFold DB: I3W353