Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3076422..3077041 Replicon chromosome
Accession NZ_CP022023
Organism Klebsiella pneumoniae strain 19051

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CDA51_RS15220 Protein ID WP_002892050.1
Coordinates 3076422..3076640 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag CDA51_RS15225 Protein ID WP_002892066.1
Coordinates 3076667..3077041 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDA51_RS15190 3072486..3072749 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
CDA51_RS15195 3072749..3072889 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CDA51_RS15200 3072886..3073584 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
CDA51_RS15205 3073685..3075119 + 1435 Protein_2858 PLP-dependent aminotransferase family protein -
CDA51_RS15210 3075094..3075564 - 471 WP_002892026.1 YlaC family protein -
CDA51_RS27095 3075585..3075725 + 141 WP_004147370.1 hypothetical protein -
CDA51_RS15215 3075697..3076263 - 567 WP_002892030.1 maltose O-acetyltransferase -
CDA51_RS15220 3076422..3076640 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CDA51_RS15225 3076667..3077041 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
CDA51_RS15230 3077527..3080673 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
CDA51_RS15235 3080696..3081889 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T78210 WP_002892050.1 NZ_CP022023:c3076640-3076422 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T78210 NZ_CP022023:c3076640-3076422 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT78210 WP_002892066.1 NZ_CP022023:c3077041-3076667 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT78210 NZ_CP022023:c3077041-3076667 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References