Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2401425..2402260 Replicon chromosome
Accession NZ_CP022023
Organism Klebsiella pneumoniae strain 19051

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag CDA51_RS11910 Protein ID WP_001559913.1
Coordinates 2401883..2402260 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag CDA51_RS11905 Protein ID WP_032408847.1
Coordinates 2401425..2401793 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDA51_RS11865 2398205..2398660 + 456 WP_000581504.1 hypothetical protein -
CDA51_RS11870 2398739..2398972 + 234 WP_001119729.1 DUF905 family protein -
CDA51_RS11880 2399072..2399890 + 819 WP_001559911.1 DUF945 domain-containing protein -
CDA51_RS11885 2399982..2400467 + 486 WP_088607457.1 antirestriction protein -
CDA51_RS11890 2400482..2400958 + 477 WP_032408846.1 RadC family protein -
CDA51_RS11895 2401027..2401248 + 222 WP_000692300.1 DUF987 domain-containing protein -
CDA51_RS11905 2401425..2401793 + 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CDA51_RS11910 2401883..2402260 + 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
CDA51_RS11915 2402257..2402745 + 489 WP_001559914.1 hypothetical protein -
CDA51_RS11920 2402765..2402962 + 198 WP_032408848.1 DUF957 domain-containing protein -
CDA51_RS27040 2403047..2403199 + 153 WP_164713811.1 hypothetical protein -
CDA51_RS26720 2403646..2404757 + 1112 Protein_2241 IS3 family transposase -
CDA51_RS26725 2404774..2404962 + 189 Protein_2242 transposase -
CDA51_RS11950 2405161..2406046 - 886 Protein_2243 RES domain-containing protein -
CDA51_RS11955 2406057..2406729 - 673 Protein_2244 DUF4400 domain-containing protein -
CDA51_RS11960 2406729..2406995 - 267 WP_004178415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2383891..2414790 30899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T78208 WP_001559913.1 NZ_CP022023:2401883-2402260 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T78208 NZ_CP022023:2401883-2402260 [Klebsiella pneumoniae]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT78208 WP_032408847.1 NZ_CP022023:2401425-2401793 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT78208 NZ_CP022023:2401425-2401793 [Klebsiella pneumoniae]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCATGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References