Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 272327..272917 Replicon plasmid unnamed1
Accession NZ_CP022016
Organism Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LFZ16_RS28600 Protein ID WP_223353822.1
Coordinates 272327..272659 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LFZ16_RS28605 Protein ID WP_223353824.1
Coordinates 272660..272917 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ16_RS28570 268091..268264 + 174 WP_223353814.1 hypothetical protein -
LFZ16_RS28575 (LFZ16_29560) 268339..270159 + 1821 WP_223353816.1 ABC transporter ATP-binding protein -
LFZ16_RS28580 270171..270671 + 501 WP_223353818.1 hypothetical protein -
LFZ16_RS28585 (LFZ16_29565) 270673..271407 + 735 WP_223353820.1 S8 family serine peptidase -
LFZ16_RS28590 (LFZ16_29570) 271411..271832 + 422 Protein_315 GDP-mannose 4,6-dehydratase -
LFZ16_RS28595 (LFZ16_29575) 271853..272044 + 192 Protein_316 transposase -
LFZ16_RS28600 (LFZ16_29580) 272327..272659 - 333 WP_223353822.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LFZ16_RS28605 (LFZ16_29585) 272660..272917 - 258 WP_223353824.1 antitoxin Antitoxin
LFZ16_RS28610 (LFZ16_29595) 273529..277428 + 3900 WP_223353826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - sopE2 / flhA / flhB / cheZ / cheY / cheB / cheR / cheW / cheA / motB / motA / flhC / flhD / fliA / fliS / fliG / fliI / fliM / fliN / fliP / fliQ / fliR / rcsA / sopA / sopA / ugd / gnd / ddhB / ddhA / galF / wcaJ / manB / wcaG / gmd / wza 1..473456 473456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11703.48 Da        Isoelectric Point: 8.5572

>T78200 WP_223353822.1 NZ_CP022016:c272659-272327 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLECIPEAVVNEVLARLEAILS

Download         Length: 333 bp

>T78200 NZ_CP022016:c272659-272327 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTGCTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGCTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGTG
CAGCTGGTTTTACCGTCTCATTGGACGGCGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGATCAGCCCAGAACCATT
GATATGGGGGCTCGGAACGGTAAGCGTTTGGAATGTATACCTGAAGCTGTCGTAAATGAAGTGCTGGCCCGATTGGAAGC
CATTCTAAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9363.81 Da        Isoelectric Point: 4.2950

>AT78200 WP_223353824.1 NZ_CP022016:c272917-272660 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPYAEMSDEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT78200 NZ_CP022016:c272917-272660 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGTATACCACTCGCCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTAGCGCT
GTCGACAGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGACCTCATTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGTACGCCGAAATGAGCGATGAGGATAGGGAATGGATTGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References