Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 85808..86399 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP022016 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | A0A974QD31 |
| Locus tag | LFZ16_RS27480 | Protein ID | WP_023246428.1 |
| Coordinates | 85808..86116 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A974QCZ9 |
| Locus tag | LFZ16_RS27485 | Protein ID | WP_023246427.1 |
| Coordinates | 86109..86399 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS27460 (LFZ16_28430) | 81463..81792 | - | 330 | WP_220540284.1 | phage tail protein | - |
| LFZ16_RS27465 (LFZ16_28435) | 81880..82194 | + | 315 | WP_223353939.1 | type II toxin-antitoxin system HigB family toxin | - |
| LFZ16_RS27470 (LFZ16_28440) | 82194..82610 | + | 417 | WP_223353941.1 | helix-turn-helix domain-containing protein | - |
| LFZ16_RS27475 (LFZ16_28445) | 82632..85745 | - | 3114 | WP_223353943.1 | phage tail tape measure protein | - |
| LFZ16_RS27480 (LFZ16_28450) | 85808..86116 | + | 309 | WP_023246428.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFZ16_RS27485 (LFZ16_28455) | 86109..86399 | + | 291 | WP_023246427.1 | putative addiction module antidote protein | Antitoxin |
| LFZ16_RS27490 (LFZ16_28460) | 86400..86618 | - | 219 | WP_023246426.1 | hypothetical protein | - |
| LFZ16_RS27495 (LFZ16_28465) | 86669..87070 | - | 402 | WP_023246425.1 | phage tail assembly chaperone | - |
| LFZ16_RS27500 (LFZ16_28470) | 87077..88054 | - | 978 | WP_223353945.1 | phage tail tube protein | - |
| LFZ16_RS27505 (LFZ16_28475) | 88059..88469 | - | 411 | WP_070804550.1 | phage tail terminator-like protein | - |
| LFZ16_RS27510 (LFZ16_28480) | 88466..88921 | - | 456 | WP_070804551.1 | HK97 gp10 family phage protein | - |
| LFZ16_RS27515 (LFZ16_28485) | 88905..89288 | - | 384 | WP_223353946.1 | hypothetical protein | - |
| LFZ16_RS27520 (LFZ16_28490) | 89291..89779 | - | 489 | WP_070804553.1 | hypothetical protein | - |
| LFZ16_RS27525 (LFZ16_28495) | 89823..90800 | - | 978 | WP_223353948.1 | major capsid protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | sopE2 / flhA / flhB / cheZ / cheY / cheB / cheR / cheW / cheA / motB / motA / flhC / flhD / fliA / fliS / fliG / fliI / fliM / fliN / fliP / fliQ / fliR / rcsA / sopA / sopA / ugd / gnd / ddhB / ddhA / galF / wcaJ / manB / wcaG / gmd / wza | 1..473456 | 473456 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11447.10 Da Isoelectric Point: 10.0661
>T78190 WP_023246428.1 NZ_CP022016:85808-86116 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MKEIIRSETFSDWLLSLKDSRAKARVLARIDRMKAGNFGDSEPIGDGLSEARIHYGPGYRVYFMQQGNVVVVLLCGGDKS
SQSKDIKQAKQIAKAWREAKND
MKEIIRSETFSDWLLSLKDSRAKARVLARIDRMKAGNFGDSEPIGDGLSEARIHYGPGYRVYFMQQGNVVVVLLCGGDKS
SQSKDIKQAKQIAKAWREAKND
Download Length: 309 bp
>T78190 NZ_CP022016:85808-86116 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGAAAGAAATAATCCGTAGTGAAACATTTTCTGACTGGTTGTTGTCTCTTAAAGACTCACGAGCAAAAGCCCGCGTGCT
TGCCCGAATAGATCGCATGAAGGCGGGTAATTTTGGAGATTCAGAACCCATTGGCGATGGACTCAGTGAAGCTCGTATCC
ACTACGGTCCAGGTTATCGGGTGTATTTCATGCAACAGGGCAACGTTGTTGTCGTTTTACTCTGTGGCGGTGATAAGAGT
TCGCAATCAAAAGATATTAAACAGGCAAAGCAAATCGCTAAGGCCTGGAGAGAGGCAAAAAATGACTGA
ATGAAAGAAATAATCCGTAGTGAAACATTTTCTGACTGGTTGTTGTCTCTTAAAGACTCACGAGCAAAAGCCCGCGTGCT
TGCCCGAATAGATCGCATGAAGGCGGGTAATTTTGGAGATTCAGAACCCATTGGCGATGGACTCAGTGAAGCTCGTATCC
ACTACGGTCCAGGTTATCGGGTGTATTTCATGCAACAGGGCAACGTTGTTGTCGTTTTACTCTGTGGCGGTGATAAGAGT
TCGCAATCAAAAGATATTAAACAGGCAAAGCAAATCGCTAAGGCCTGGAGAGAGGCAAAAAATGACTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10357.71 Da Isoelectric Point: 4.6127
>AT78190 WP_023246427.1 NZ_CP022016:86109-86399 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MTEQFAQWDTAEYLKTEEDMAEYLNACMEEAGDDPAFIAKALGTIARARGMTQVARDAGVSRESLYRALSGSGNPEFGTI
LKVVKALGLKLHSTAA
MTEQFAQWDTAEYLKTEEDMAEYLNACMEEAGDDPAFIAKALGTIARARGMTQVARDAGVSRESLYRALSGSGNPEFGTI
LKVVKALGLKLHSTAA
Download Length: 291 bp
>AT78190 NZ_CP022016:86109-86399 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGACTGAACAATTTGCACAATGGGATACAGCGGAATACCTGAAAACGGAAGAGGATATGGCTGAATATCTGAACGCCTG
CATGGAAGAAGCCGGAGACGATCCCGCTTTCATCGCAAAAGCGCTTGGCACCATTGCCCGCGCCCGTGGAATGACACAAG
TTGCCCGTGATGCAGGTGTATCCCGTGAGAGTCTGTATCGAGCCCTTTCTGGTAGCGGCAATCCTGAGTTTGGCACCATT
CTGAAAGTCGTTAAGGCGCTTGGTCTGAAACTTCACTCGACGGCAGCGTGA
ATGACTGAACAATTTGCACAATGGGATACAGCGGAATACCTGAAAACGGAAGAGGATATGGCTGAATATCTGAACGCCTG
CATGGAAGAAGCCGGAGACGATCCCGCTTTCATCGCAAAAGCGCTTGGCACCATTGCCCGCGCCCGTGGAATGACACAAG
TTGCCCGTGATGCAGGTGTATCCCGTGAGAGTCTGTATCGAGCCCTTTCTGGTAGCGGCAATCCTGAGTTTGGCACCATT
CTGAAAGTCGTTAAGGCGCTTGGTCTGAAACTTCACTCGACGGCAGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|