Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 4910407..4910957 | Replicon | chromosome |
| Accession | NZ_CP022015 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A5J1IE68 |
| Locus tag | LFZ16_RS24650 | Protein ID | WP_023212786.1 |
| Coordinates | 4910649..4910957 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7RP97 |
| Locus tag | LFZ16_RS24645 | Protein ID | WP_001118105.1 |
| Coordinates | 4910407..4910646 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS24600 (4905685) | 4905685..4905831 | + | 147 | WP_023892166.1 | hypothetical protein | - |
| LFZ16_RS24605 (4905848) | 4905848..4906051 | + | 204 | WP_000508162.1 | hypothetical protein | - |
| LFZ16_RS24610 (4906116) | 4906116..4907036 | + | 921 | WP_223353740.1 | inhibitor of vertebrate lysozyme family protein | - |
| LFZ16_RS24615 (4907121) | 4907121..4907761 | + | 641 | Protein_4814 | DUF945 domain-containing protein | - |
| LFZ16_RS24620 (4907774) | 4907774..4908274 | + | 501 | WP_023212790.1 | DNA repair protein RadC | - |
| LFZ16_RS24625 (4908337) | 4908337..4908666 | + | 330 | WP_023212789.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| LFZ16_RS24630 (4908681) | 4908681..4908998 | + | 318 | Protein_4817 | toxin | - |
| LFZ16_RS24635 (4909140) | 4909140..4909973 | + | 834 | WP_023212788.1 | DUF4942 domain-containing protein | - |
| LFZ16_RS24640 (4910050) | 4910050..4910298 | + | 249 | WP_023212787.1 | ribbon-helix-helix domain-containing protein | - |
| LFZ16_RS24645 (4910407) | 4910407..4910646 | + | 240 | WP_001118105.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| LFZ16_RS24650 (4910649) | 4910649..4910957 | + | 309 | WP_023212786.1 | CcdB family protein | Toxin |
| LFZ16_RS24655 (4910991) | 4910991..4911509 | - | 519 | Protein_4822 | TIGR03746 family integrating conjugative element protein | - |
| LFZ16_RS29660 (4911506) | 4911506..4911670 | - | 165 | WP_238705881.1 | DUF3487 family protein | - |
| LFZ16_RS24660 (4911621) | 4911621..4911860 | - | 240 | WP_023212784.1 | DUF3487 family protein | - |
| LFZ16_RS24665 (4911862) | 4911862..4912179 | - | 318 | WP_023212783.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| LFZ16_RS24670 (4912189) | 4912189..4912422 | - | 234 | WP_023212782.1 | TIGR03758 family integrating conjugative element protein | - |
| LFZ16_RS24675 (4912415) | 4912415..4912723 | - | 309 | WP_023212781.1 | RAQPRD family integrative conjugative element protein | - |
| LFZ16_RS24680 (4913019) | 4913019..4915466 | - | 2448 | WP_052942568.1 | AAA family ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | cheD | 4875909..4958217 | 82308 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11859.69 Da Isoelectric Point: 6.7228
>T78188 WP_023212786.1 NZ_CP022015:4910649-4910957 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLINNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLINNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF
Download Length: 309 bp
>T78188 NZ_CP022015:4910649-4910957 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGATAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGATAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8719.90 Da Isoelectric Point: 6.4633
>AT78188 WP_001118105.1 NZ_CP022015:4910407-4910646 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF
Download Length: 240 bp
>AT78188 NZ_CP022015:4910407-4910646 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1IE68 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H9SZK8 |