Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4828946..4829462 Replicon chromosome
Accession NZ_CP022015
Organism Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LFZ16_RS24215 Protein ID WP_000220578.1
Coordinates 4829178..4829462 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I1C3W3
Locus tag LFZ16_RS24210 Protein ID WP_000212722.1
Coordinates 4828946..4829188 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ16_RS24190 (4823966) 4823966..4825099 + 1134 WP_223352733.1 amidohydrolase/deacetylase family metallohydrolase -
LFZ16_RS24195 (4825083) 4825083..4826201 + 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LFZ16_RS24200 (4826198) 4826198..4826938 + 741 WP_000779263.1 KDGP aldolase family protein -
LFZ16_RS24205 (4826955) 4826955..4828868 + 1914 WP_023212815.1 BglG family transcription antiterminator -
LFZ16_RS24210 (4828946) 4828946..4829188 + 243 WP_000212722.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LFZ16_RS24215 (4829178) 4829178..4829462 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LFZ16_RS24220 (4829466) 4829466..4829930 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LFZ16_RS24225 (4830147) 4830147..4832285 - 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
LFZ16_RS24230 (4832694) 4832694..4834346 - 1653 WP_223352734.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T78187 WP_000220578.1 NZ_CP022015:4829178-4829462 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T78187 NZ_CP022015:4829178-4829462 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8988.37 Da        Isoelectric Point: 5.0651

>AT78187 WP_000212722.1 NZ_CP022015:4828946-4829188 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDNEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT78187 NZ_CP022015:4828946-4829188 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACTGTCACTCTTAGCGACA
ATGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1C3W3

References