Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3165007..3165746 Replicon chromosome
Accession NZ_CP022015
Organism Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)


Gene name tacT Uniprot ID A0A974KH57
Locus tag LFZ16_RS16070 Protein ID WP_070802821.1
Coordinates 3165261..3165746 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LFZ16_RS16065 Protein ID WP_223352402.1
Coordinates 3165007..3165273 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ16_RS16050 (3160253) 3160253..3161620 - 1368 WP_080214213.1 DUF4147 domain-containing protein -
LFZ16_RS16055 (3161680) 3161680..3162996 - 1317 WP_080214214.1 MFS transporter -
LFZ16_RS16060 (3163129) 3163129..3164421 - 1293 WP_000097706.1 phosphopyruvate hydratase -
LFZ16_RS16065 (3165007) 3165007..3165273 + 267 WP_223352402.1 DUF1778 domain-containing protein Antitoxin
LFZ16_RS16070 (3165261) 3165261..3165746 + 486 WP_070802821.1 GNAT family N-acetyltransferase Toxin
LFZ16_RS16075 (3166140) 3166140..3166643 - 504 Protein_3156 single-stranded DNA-binding protein -
LFZ16_RS16080 (3166656) 3166656..3166874 - 219 WP_001750504.1 hypothetical protein -
LFZ16_RS16085 (3166967) 3166967..3167431 - 465 WP_023222080.1 STY4534 family ICE replication protein -
LFZ16_RS16090 (3168130) 3168130..3170154 - 2025 WP_070802825.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(54-152)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17784.61 Da        Isoelectric Point: 10.0695

>T78182 WP_070802821.1 NZ_CP022015:3165261-3165746 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
VGRVTAPEPLSALHQVAEFVSGEVVLDDWLKQRGLKNQDLGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKKFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T78182 NZ_CP022015:3165261-3165746 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
GTGGGACGTGTAACAGCACCAGAACCTTTATCCGCTCTTCATCAGGTGGCGGAGTTTGTCAGCGGTGAAGTCGTGCTCGA
TGACTGGTTAAAGCAAAGGGGTCTCAAAAACCAGGATCTCGGAGCGGCCCGAACTTTTGTGGTTTGTAAGAAGGACACTA
AACAAATAGCCGGCTTTTACTCTTTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAATATG
CCAGACCCCATTCCTGTCATTATACTTGCCCGCTTGGCTGTCGATGTCTCATTCCGTGGAAAAGGGCTTGGTGCTGATTT
ACTGCATGACGCAGTGCTTCGTTGCTATCGGGTAGCCGAGAATATTGGTGTACGTGCAATCATGGTCCACGCGCTTACGG
AAGAAGCCAAAAAATTCTATATTCACCATGGTTTCAAACCATCACAAACTCAGCAGCGGACATTGTTCCTGAAACTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10043.51 Da        Isoelectric Point: 4.5024

>AT78182 WP_223352402.1 NZ_CP022015:3165007-3165273 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MKSDVQLNLRAKESQRALIDAAADILHKSRTDFILEIACKAAEDVILARRVFNFNDEQYAEFIDMIDAPVADDPVIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT78182 NZ_CP022015:3165007-3165273 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGAAATCAGATGTTCAACTCAACCTTAGGGCCAAAGAATCCCAGCGAGCACTCATTGATGCCGCTGCTGATATCCTTCA
CAAATCACGTACAGATTTCATTCTGGAAATAGCCTGTAAGGCGGCCGAGGATGTTATCCTCGCCCGCCGCGTCTTTAATT
TTAACGATGAGCAATACGCAGAGTTCATTGATATGATTGATGCACCGGTCGCAGATGATCCCGTTATCGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References