Detailed information of TA system TA078181

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 3154181..3154938
• Replicon: chromosome
• Accession: NZ_CP022015
• Organism: Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: LFZ16_RS16015
• Protein ID: WP_077957978.1
• Coordinates: 3154456..3154938 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A974KCP6
• Locus tag: LFZ16_RS16010
• Protein ID: WP_070802811.1
• Coordinates: 3154181..3154465 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ16_RS15995 (3150362)	3150362..3152046	-	1685	Protein_3141	PilN family type IVB pilus formation outer membrane protein	-
LFZ16_RS16000 (3152067)	3152067..3152504	-	438	WP_223352399.1	type IV pilus biogenesis protein PilM	-
LFZ16_RS16005 (3152504)	3152504..3153790	-	1287	WP_070802848.1	TcpQ domain-containing protein	-
LFZ16_RS16010 (3154181)	3154181..3154465	+	285	WP_070802811.1	DUF1778 domain-containing protein	Antitoxin
LFZ16_RS16015 (3154456)	3154456..3154938	+	483	WP_077957978.1	GNAT family N-acetyltransferase	Toxin
LFZ16_RS16025 (3155515)	3155515..3155901	-	387	WP_070802853.1	prolyl endopeptidase	-
LFZ16_RS16030 (3156447)	3156447..3157013	-	567	WP_077957979.1	GNAT family N-acetyltransferase	-
LFZ16_RS16035 (3157010)	3157010..3158455	-	1446	WP_070802815.1	pyruvate kinase	-
LFZ16_RS16040 (3158568)	3158568..3159227	-	660	WP_023245797.1	GntR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-87)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17994.77 Da
• Isoelectric Point: 7.7481

>T78181 WP_077957978.1 NZ_CP022015:3154456-3154938 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MEINVTAPELLNKEHILQSFDCGNDVLSDWLRRRAMKNQHLNASRTFVICLECTKRVVGYYSIATGSISHVDLGRSLHQN
MPDPVPVVLLGRLAIDKCTQGQNFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKAFYEYFGFVQSPIAPNTLFYKI

Nucleotide

• Length: 483 bp

>T78181 NZ_CP022015:3154456-3154938 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGAAATAAATGTTACTGCACCTGAGCTGCTGAACAAGGAGCATATTCTCCAATCTTTCGATTGCGGGAATGATGTATT
AAGCGACTGGCTTCGCCGCCGCGCTATGAAGAATCAGCACCTCAATGCATCCCGTACATTTGTGATCTGCCTTGAATGCA
CAAAACGCGTAGTAGGATATTATTCTATTGCTACGGGATCTATAAGCCATGTCGATTTAGGTCGCAGCCTGCATCAGAAT
ATGCCCGATCCTGTTCCAGTTGTTTTATTGGGACGTCTTGCTATTGATAAGTGTACTCAGGGTCAAAATTTCGGTAAATG
GCTGCTTAATGATGCTGTAACGCGAGTATCAAACCTGGCAGATCAGGTGGGGATTAAAGCGATCATGGTGCATGCTATTG
ATGAACAAGCGAAAGCATTCTATGAATATTTTGGCTTCGTTCAGTCCCCCATTGCACCAAACACATTGTTCTACAAGATT
TAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11029.59 Da
• Isoelectric Point: 8.5171

>AT78181 WP_070802811.1 NZ_CP022015:3154181-3154465 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MQTTPRKSIRNKQINIRATDEERAVIDYAAKLVSKNRTDFIIEKAVNEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRQRLMDVKPEWK

Nucleotide

• Length: 285 bp

>AT78181 NZ_CP022015:3154181-3154465 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGCAAACTACGCCCCGTAAATCTATTCGTAATAAACAAATAAATATTCGAGCGACTGATGAGGAACGCGCAGTAATTGA
CTATGCAGCAAAGTTGGTCAGTAAAAATCGCACTGATTTCATCATAGAGAAAGCTGTGAATGAAGCTCAGAATATCATTC
TGGATCAGCGAGTTTTCGTTCTGGATGATGCTCGTTACCAGGCATTCATTGAACAGCTCGAAGCCCCAGTTCAGAATGTT
GAGGGTCGTCAGCGGCTGATGGATGTAAAACCTGAATGGAAATAA