Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2906411..2907071 Replicon chromosome
Accession NZ_CP022015
Organism Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LFZ16_RS14785 Protein ID WP_000244756.1
Coordinates 2906411..2906824 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LFZ16_RS14790 Protein ID WP_000351186.1
Coordinates 2906805..2907071 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ16_RS14765 (2902352) 2902352..2904085 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
LFZ16_RS14770 (2904091) 2904091..2904804 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LFZ16_RS14775 (2904828) 2904828..2905724 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LFZ16_RS14780 (2905837) 2905837..2906358 + 522 WP_023212713.1 flavodoxin FldB -
LFZ16_RS14785 (2906411) 2906411..2906824 - 414 WP_000244756.1 protein YgfX Toxin
LFZ16_RS14790 (2906805) 2906805..2907071 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LFZ16_RS14795 (2907321) 2907321..2908301 + 981 WP_000874169.1 tRNA-modifying protein YgfZ -
LFZ16_RS14800 (2908417) 2908417..2909076 - 660 WP_000250289.1 hemolysin III family protein -
LFZ16_RS14805 (2909240) 2909240..2909551 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LFZ16_RS14810 (2909709) 2909709..2911142 + 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T78180 WP_000244756.1 NZ_CP022015:c2906824-2906411 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T78180 NZ_CP022015:c2906824-2906411 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT78180 WP_000351186.1 NZ_CP022015:c2907071-2906805 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT78180 NZ_CP022015:c2907071-2906805 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References