Detailed information of TA system TA078177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1555479..1556052
• Replicon: chromosome
• Accession: NZ_CP022015
• Organism: Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: LFZ16_RS07885
• Protein ID: WP_079919438.1
• Coordinates: 1555479..1555775 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LFZ16_RS07890
• Protein ID: WP_223353260.1
• Coordinates: 1555777..1556052 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ16_RS07860 (1552045)	1552045..1552425	+	381	WP_223353257.1	hypothetical protein	-
LFZ16_RS07865 (1552406)	1552406..1553389	+	984	WP_223353258.1	tyrosine-type recombinase/integrase	-
LFZ16_RS07870 (1553829)	1553829..1554284	+	456	WP_223353697.1	single-stranded DNA-binding protein	-
LFZ16_RS07875 (1554338)	1554338..1554937	+	600	WP_223353259.1	ProQ/FinO family protein	-
LFZ16_RS07880 (1554927)	1554927..1555139	+	213	WP_023246566.1	hypothetical protein	-
LFZ16_RS07885 (1555479)	1555479..1555775	+	297	WP_079919438.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LFZ16_RS07890 (1555777)	1555777..1556052	+	276	WP_223353260.1	putative addiction module antidote protein	Antitoxin
LFZ16_RS07895 (1556089)	1556089..1556427	+	339	WP_223353261.1	transcriptional regulator	-
LFZ16_RS07900 (1556788)	1556788..1556961	+	174	WP_223353262.1	hypothetical protein	-
LFZ16_RS07905 (1556958)	1556958..1557311	+	354	WP_223353263.1	hypothetical protein	-
LFZ16_RS07910 (1557413)	1557413..1558126	+	714	WP_223353264.1	hypothetical protein	-
LFZ16_RS07915 (1558139)	1558139..1558666	+	528	WP_223353265.1	hypothetical protein	-
LFZ16_RS07920 (1559180)	1559180..1559770	+	591	WP_223353266.1	hypothetical protein	-
LFZ16_RS07925 (1560112)	1560112..1560315	-	204	WP_223353267.1	hypothetical protein	-
LFZ16_RS07930 (1560331)	1560331..1560720	-	390	WP_223353268.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	sopD2	1533894..1571908	38014

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-95)

Antitoxin

• Uncharacterized protein HI1420 (6-90)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11097.91 Da
• Isoelectric Point: 10.3907

>T78177 WP_079919438.1 NZ_CP022015:1555479-1555775 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MIDIKTTPEAEKWLKGLKDRVAKSKILIRIDRMRTGNFGDVEPVGGGLSELRIHHGKGYRVYFGNKNNEIILILCGGDKS
TQQEDIQKAKQIAKKWGF

Nucleotide

• Length: 297 bp

>T78177 NZ_CP022015:1555479-1555775 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGATTGACATAAAAACAACACCAGAGGCCGAGAAGTGGCTAAAGGGATTGAAAGACCGGGTAGCGAAATCAAAGATATT
AATCAGAATCGACAGAATGAGAACGGGGAACTTTGGTGATGTTGAGCCAGTAGGCGGCGGGTTATCTGAATTGCGCATAC
ATCACGGCAAAGGTTATCGGGTTTATTTTGGGAATAAAAACAACGAAATAATATTAATTCTTTGTGGCGGGGATAAAAGC
ACACAGCAGGAAGATATACAGAAAGCGAAACAGATAGCCAAAAAATGGGGGTTTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10109.50 Da
• Isoelectric Point: 4.7683

>AT78177 WP_223353260.1 NZ_CP022015:1555777-1556052 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MKQVLKDFDVADYLEDEDDIIAYLNAVIAEGDNKQLFIALGNIARARNISRISKETGISREGIYKALSGDGNPSFNTLFK
ITKAMGLDLHF

Nucleotide

• Length: 276 bp

>AT78177 NZ_CP022015:1555777-1556052 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGAAACAGGTATTAAAAGATTTTGACGTCGCAGACTATTTAGAGGACGAAGATGACATTATCGCCTATCTGAATGCCGT
TATTGCCGAGGGTGACAATAAACAACTTTTCATTGCGCTGGGCAACATTGCAAGAGCAAGAAATATAAGCCGTATTTCAA
AAGAAACCGGAATCAGCAGGGAGGGGATTTATAAAGCACTTTCAGGTGATGGAAATCCATCATTTAACACCCTTTTTAAA
ATAACTAAAGCGATGGGGTTAGATCTTCACTTTTAA