Detailed information of TA system TA078176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1060285..1060905
• Replicon: chromosome
• Accession: NZ_CP022015
• Organism: Salmonella enterica subsp. enterica serovar India str. SA20085604

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LFZ16_RS05385
• Protein ID: WP_001280991.1
• Coordinates: 1060285..1060503 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LFZ16_RS05390
• Protein ID: WP_000344807.1
• Coordinates: 1060531..1060905 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ16_RS05345 (1055508)	1055508..1056077	+	570	WP_000779802.1	YbaY family lipoprotein	-
LFZ16_RS05350 (1056110)	1056110..1056499	-	390	WP_000961285.1	MGMT family protein	-
LFZ16_RS05360 (1056730)	1056730..1058280	-	1551	WP_000213140.1	EAL domain-containing protein	-
LFZ16_RS05365 (1058505)	1058505..1058765	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LFZ16_RS05370 (1058771)	1058771..1058911	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LFZ16_RS05375 (1058967)	1058967..1059437	-	471	WP_000136183.1	YlaC family protein	-
LFZ16_RS05380 (1059555)	1059555..1060106	-	552	WP_001278793.1	maltose O-acetyltransferase	-
LFZ16_RS05385 (1060285)	1060285..1060503	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
LFZ16_RS05390 (1060531)	1060531..1060905	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LFZ16_RS05395 (1061401)	1061401..1064550	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LFZ16_RS05400 (1064573)	1064573..1065766	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T78176 WP_001280991.1 NZ_CP022015:c1060503-1060285 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T78176 NZ_CP022015:c1060503-1060285 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAAATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT78176 WP_000344807.1 NZ_CP022015:c1060905-1060531 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT78176 NZ_CP022015:c1060905-1060531 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0