Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3133892..3134496 Replicon chromosome
Accession NZ_CP022014
Organism Mycobacterium tuberculosis strain MTB2

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag B7R63_RS15455 Protein ID WP_003414492.1
Coordinates 3133892..3134284 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag B7R63_RS15460 Protein ID WP_003414495.1
Coordinates 3134281..3134496 (-) Length 72 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R63_RS15425 3129042..3129830 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
B7R63_RS15430 3130164..3130709 - 546 WP_014584866.1 DUF1802 family protein -
B7R63_RS15435 3130981..3131865 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
B7R63_RS15440 3131868..3132755 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
B7R63_RS15445 3133060..3133605 - 546 WP_003899500.1 DUF1802 family protein -
B7R63_RS15450 3133602..3133871 - 270 WP_003414489.1 DUF2277 family protein -
B7R63_RS15455 3133892..3134284 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
B7R63_RS15460 3134281..3134496 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B7R63_RS15465 3134543..3135292 + 750 WP_003902358.1 enoyl-CoA hydratase -
B7R63_RS15470 3135371..3136453 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
B7R63_RS15475 3136446..3137756 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
B7R63_RS15480 3137759..3138586 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
B7R63_RS15485 3138583..3139494 - 912 WP_003902360.1 sugar ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T78168 WP_003414492.1 NZ_CP022014:c3134284-3133892 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T78168 NZ_CP022014:c3134284-3133892 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT78168 WP_003414495.1 NZ_CP022014:c3134496-3134281 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT78168 NZ_CP022014:c3134496-3134281 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8


Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References