Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2863709..2864418 Replicon chromosome
Accession NZ_CP022014
Organism Mycobacterium tuberculosis strain MTB2

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag B7R63_RS13905 Protein ID WP_003413164.1
Coordinates 2863709..2864122 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag B7R63_RS13910 Protein ID WP_003413167.1
Coordinates 2864161..2864418 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R63_RS13870 2858763..2859968 - 1206 WP_003413027.1 chorismate synthase -
B7R63_RS13875 2860076..2860390 + 315 WP_009937839.1 hypothetical protein -
B7R63_RS13880 2860686..2861897 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
B7R63_RS13890 2862024..2862683 + 660 WP_003902296.1 hypothetical protein -
B7R63_RS13895 2862680..2863342 + 663 WP_003905878.1 hypothetical protein -
B7R63_RS21545 2863339..2863616 + 278 Protein_2627 type II toxin-antitoxin system VapB family antitoxin -
B7R63_RS13905 2863709..2864122 + 414 WP_003413164.1 PIN domain nuclease Toxin
B7R63_RS13910 2864161..2864418 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
B7R63_RS13915 2864415..2864792 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
B7R63_RS13920 2864808..2865182 - 375 WP_003413177.1 hypothetical protein -
B7R63_RS13925 2865282..2865677 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
B7R63_RS13930 2865674..2865919 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
B7R63_RS13940 2866330..2866749 - 420 WP_003413190.1 A24 family peptidase -
B7R63_RS13945 2866761..2867570 - 810 WP_003413193.1 shikimate dehydrogenase -
B7R63_RS13950 2867567..2868817 - 1251 WP_024753809.1 endolytic transglycosylase MltG -
B7R63_RS13955 2868810..2869322 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T78159 WP_003413164.1 NZ_CP022014:2863709-2864122 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T78159 NZ_CP022014:2863709-2864122 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT78159 WP_003413167.1 NZ_CP022014:2864161-2864418 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT78159 NZ_CP022014:2864161-2864418 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References